Journal article
Sex differences in maternal gestational hypertension-induced sensitization of angiotensin II hypertension in rat offspring: the protective effect of estrogen
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.314(2), pp.R274-R281
02/01/2018
DOI: 10.1152/ajpregu.00216.2017
PMCID: PMC5867674
PMID: 29046315
Abstract
Recent studies demonstrate that maternal hypertension during pregnancy sensitizes an angiotensin (ANG) II-induced increase in blood pressure (BP) in adult male offspring that was associated with upregulation of mRNA expression of several renin-angiotensin-aldosterone system (RAAS) components and NADPH oxidase in the lamina terminalis (LT) and paraventricular nucleus (PVN). The purpose of the present study was to test whether there are sex differences in the maternal hypertension-induced sensitization of ANG II hypertension, and whether sex hormones are involved in the sensitization process. Male offspring of hypertensive dams showed an enhanced hypertensive response to systemic ANG II when compared with male offspring of normotensive dams and to female offspring of either normotensive or hypertensive dams. Castration did not alter the hypertensive response to ANG II in male offspring. Intact female offspring had no upregulation of RAAS components and NADPH oxidase in the LT and PVN, whereas ovariectomy (OVX) upregulated mRNA expression of several RAAS components and NADPH oxidase in these nuclei and induced a greater increase in the pressor response to ANG II in female offspring of hypertensive dams compared with female offspring of normotensive dams. This enhanced increase in BP was partially attenuated by 17β-estradiol replacement in the OVX offspring of hypertensive dams. The results suggest that maternal hypertension induces a sex-specific sensitization of ANG II-induced hypertension and mRNA expression of brain RAAS and NADPH oxidase in offspring. Female offspring are protected from maternal hypertension-induced sensitization of ANG II hypertension, and female sex hormones are partially responsible for this protective effect.
Details
- Title: Subtitle
- Sex differences in maternal gestational hypertension-induced sensitization of angiotensin II hypertension in rat offspring: the protective effect of estrogen
- Creators
- Baojian Xue - François M. Abboud Cardiovascular Research Center, University of Iowa , Iowa City, IowaTerry G Beltz - Department of Psychological and Brain Sciences, University of Iowa , Iowa City, IowaFang Guo - Department of Psychological and Brain Sciences, University of Iowa , Iowa City, IowaAlan Kim Johnson - François M. Abboud Cardiovascular Research Center, University of Iowa , Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.314(2), pp.R274-R281
- Publisher
- United States
- DOI
- 10.1152/ajpregu.00216.2017
- PMID
- 29046315
- PMCID
- PMC5867674
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Grant note
- P01 HL014388 / NHLBI NIH HHS
- Language
- English
- Date published
- 02/01/2018
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health and Human Physiology
- Record Identifier
- 9984002473802771
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