Journal article
Sex-specific alterations in preterm brain
Pediatric research, Vol.85(1), pp.55-62
01/2019
DOI: 10.1038/s41390-018-0187-5
PMCID: PMC6353678
PMID: 30279607
Abstract
The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age.
The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures.
There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females.
Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.
Details
- Title: Subtitle
- Sex-specific alterations in preterm brain
- Creators
- Amanda Benavides - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAAndrew Metzger - Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAAlexander Tereshchenko - Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAAmy Conrad - Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAEdward F Bell - Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAJohn Spencer - School of Psychology, University of East Anglia, Norwich, EnglandShannon Ross-Sheehy - Department of Psychology, University of Tennessee, Knoxville, TN, 37996, USAMichael Georgieff - Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, MN, 55455, USAVince Magnotta - Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USAPeg Nopoulos - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA. peggy-nopoulos@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.85(1), pp.55-62
- DOI
- 10.1038/s41390-018-0187-5
- PMID
- 30279607
- PMCID
- PMC6353678
- NLM abbreviation
- Pediatr Res
- ISSN
- 1530-0447
- eISSN
- 1530-0447
- Publisher
- United States
- Grant note
- T32 MH019113 / NIMH NIH HHS P01 HL046925 / NHLBI NIH HHS K23 DE024511 / NIDCR NIH HHS U54 TR001013 / NCATS NIH HHS T32 GM007337 / NIGMS NIH HHS
- Language
- English
- Date published
- 01/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Neonatology
- Record Identifier
- 9984003479302771
Metrics
36 Record Views