Sex-specific associations of reservoir-excess pressure parameters with age and subclinical vascular remodelling

Colin J Gimblet; Matthew K Armstrong; Virginia R Nuckols; Lyndsey E DuBose; Seth W Holwerda; Rachel E Luehrs; Abbi D Lane; Michelle W Voss; Gary L Pierce

doi:10.1097/HJH.0000000000003378

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Sex-specific associations of reservoir-excess pressure parameters with age and subclinical vascular remodelling

Journal article

Peer reviewed

Sex-specific associations of reservoir-excess pressure parameters with age and subclinical vascular remodelling

Colin J Gimblet, Matthew K Armstrong, Virginia R Nuckols, Lyndsey E DuBose, Seth W Holwerda, Rachel E Luehrs, Abbi D Lane, Michelle W Voss and Gary L Pierce

Journal of hypertension, Vol.41(4), pp.624-631

04/2023

DOI: 10.1097/HJH.0000000000003378

PMCID: PMC10980292

PMID: 36723472

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Abstract

Central artery reservoir pressure and excess pressure (XSP) are associated with cardiovascular disease (CVD) events and mortality. However, sex differences in the trajectory of central reservoir pressure and XSP with advancing age and their relations with vascular markers of subclinical CVD risk are incompletely understood. Therefore, we tested the hypothesis that central reservoir pressure and XSP would be positively associated with advancing age and vascular markers of subclinical CVD risk in men and women. Healthy adults (n = 398; aged 18-80 years, 60% female individuals) had central (carotid) artery pressure waveforms acquired by applanation tonometry. Reservoir pressure and XSP peaks and integrals were derived retrospectively from carotid pressure waveforms using custom written software. Carotid artery intimal-medial thickness (IMT) was measured by ultrasonography, and aortic stiffness was determined from carotid-femoral pulse wave velocity (cfPWV). Reservoir pressure peak, reservoir pressure integral and XSP integral were higher with age in both men and women (P < 0.05), whereas XSP peak was lower with age in men (P < 0.05). In women, both reservoir pressure peak (β = 0.231, P < 0.01) and reservoir pressure integral (β = 0.254, P < 0.01) were associated with carotid artery IMT, and reservoir pressure peak was associated with cfPWV (β = 0.120, P = 0.02) after adjusting for CVD risk factors. Central artery reservoir pressure and XSP were higher with advancing age in men and women, and reservoir pressure peak was associated with both carotid artery wall thickness and aortic stiffness in women but not men. Central reservoir pressure peak may provide some insight into sex differences in vascular remodeling and subclinical CVD risk with advancing age in healthy adults.

Details

Title: Subtitle: Sex-specific associations of reservoir-excess pressure parameters with age and subclinical vascular remodelling
Creators: Colin J Gimblet - Department of Health and Human Physiology
Matthew K Armstrong - Department of Health and Human Physiology
Virginia R Nuckols - Department of Health and Human Physiology
Lyndsey E DuBose - University of Colorado Anschutz Medical Campus
Seth W Holwerda - University of Kansas Medical Center
Rachel E Luehrs - Department of Kinesiology, North Central College, Naperville, Illinois
Abbi D Lane - University of South Carolina
Michelle W Voss - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA
Gary L Pierce - University of Iowa
Resource Type: Journal article
Publication Details: Journal of hypertension, Vol.41(4), pp.624-631
DOI: 10.1097/HJH.0000000000003378
PMID: 36723472
PMCID: PMC10980292
NLM abbreviation: J Hypertens
ISSN: 0263-6352
eISSN: 1473-5598
Language: English
Electronic publication date: 02/02/2023
Date published: 04/2023
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Health, Sport, and Human Physiology ; Internal Medicine
Record Identifier: 9984365158502771

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