Journal article
Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia
Journal of applied physiology (1985), Vol.139(5), pp.1189-1194
11/01/2025
DOI: 10.1152/japplphysiol.00706.2025
PMCID: PMC12590564
PMID: 41026884
Abstract
Cancer cachexia, a multifactorial condition resulting in muscle and adipose tissue wasting, reduces the quality of life of many people with cancer. Cachexia is highly prevalent in people with pancreatic ductal adenocarcinoma (PDAC), and many animal models of pancreatic cancer are used to understand mechanisms underlying cachexia. One such model is the
,
,
(KPP) model, which utilizes an inducible Cre recombinase to initiate tumor development by tamoxifen administration. In our previous work, tumors were induced in KPP mice at 4 weeks of age. However, mice are rapidly growing at this age, and a portion of the body weight differences seen between control and KPP mice is likely due to slowed growth of KPP mice. In our current study, pancreatic tumors were induced to develop with tamoxifen in KPP mice after rapid postnatal growth has slowed at 10 weeks of age (KPP10). Given the expanding evidence of sexual dimorphisms in cancer cachexia, we utilized both male and female mice to assess potential sex differences. Similar to our previous findings, KPP10 mice had lower body, muscle, and adipose tissue weights compared to non-tumor mice, and these differences were similar between male and female mice. However, male mice experienced greater relative weight loss. Unexpectedly, we identified that survival was significantly shorter in female KPP10 mice compared to KPP10 males. Greater body weight at tumor induction was associated with longer survival, suggesting that the sex difference in survival may be related to differences in body weight between male and female mice.
Details
- Title: Subtitle
- Sex-specific survival but not tissue wasting in the KPP mouse model of pancreatic cancer-induced cachexia
- Creators
- Natalia M Weinzierl - University of IowaJayarani Putri - University of Iowa, Stead Family Department of PediatricsKathryn M Spitler - University of IowaErin E Talbert - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.139(5), pp.1189-1194
- DOI
- 10.1152/japplphysiol.00706.2025
- PMID
- 41026884
- PMCID
- PMC12590564
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- AMER PHYSIOLOGICAL SOC
- Grant note
- T32DK112751 / HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R00AR071508 / HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R21CA257972 / HHS | NIH | National Cancer Institute (NCI) N/A / Iowa Office of Undergraduate Research P30CA086862 / HHS | NIH | National Cancer Institute (NCI)
- Language
- English
- Electronic publication date
- 09/30/2025
- Date published
- 11/01/2025
- Academic Unit
- Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984969238302771
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