Journal article
Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: The effect on cognitive functioning
Progress in neuro-psychopharmacology & biological psychiatry, Vol.35(2), pp.616-623
03/30/2011
DOI: 10.1016/j.pnpbp.2011.01.005
PMCID: PMC3880827
PMID: 21237230
Abstract
Previous investigations have revealed sex-specific differences in brain morphometry. The effect of sex on cortical thickness may be influencing cognitive differences between sexes. With this exploratory study, we aimed to investigate the effect of sex in MRI-based cerebral cortex morphometry in healthy young volunteers and how the variability in cortical measures might affect cognitive functioning in men and women. 76 young healthy volunteers (45 men and 31 women) underwent a 1.5T MR scan and 53 of them completed a comprehensive cognitive battery. Overall no gross significant differences between sexes were found in cortical thickness, surface area and curvature indexes. However, there was a significant group by hemisphere interaction in the total cortical thickness (F(1,72)=5.02; p=0.03). A greater leftward asymmetry was observed in cortical thickness in males. Only females show significant associations between cortical thickness and cognitive functioning (IQ and executive functioning). In conclusion, our findings do not support the notion of sexual dimorphism in cortical mantle morphology. The results also suggest that variability in cortical thickness may affect cognitive functioning in females but not in males.
► We did not find significant differences in cortical depth, surface area and curvature indexes. ► The asymmetry profile seems to be influenced by sex. ► Women show significant associations between cortical depth and IQ and executive functioning.
Details
- Title: Subtitle
- Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: The effect on cognitive functioning
- Creators
- Benedicto Crespo-Facorro - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, SpainRoberto Roiz-Santiáñez - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, SpainRocío Pérez-Iglesias - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, SpainIgnacio Mata - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, SpainJose Manuel Rodríguez-Sánchez - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, SpainDiana Tordesillas-Gutiérrez - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, SpainVictor Ortíz-García de la Foz - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, SpainRafael Tabarés-Seisdedos - Teaching Unit of Psychiatry and Psychological Medicine, CIBERSAM, Department of Medicine, University of Valencia, Valencia, SpainElena Sánchez - University Hospital Marqués de Valdecilla, Department of Neuroradiology, Santander, SpainNancy Andreasen - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USAVicent Magnotta - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USAJosé Luis Vázquez-Barquero - University Hospital Marqués de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
- Resource Type
- Journal article
- Publication Details
- Progress in neuro-psychopharmacology & biological psychiatry, Vol.35(2), pp.616-623
- DOI
- 10.1016/j.pnpbp.2011.01.005
- PMID
- 21237230
- PMCID
- PMC3880827
- NLM abbreviation
- Prog Neuropsychopharmacol Biol Psychiatry
- ISSN
- 0278-5846
- eISSN
- 1878-4216
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/501100004587, name: Instituto de Salud Carlos III, award: PI020499, PI050427, PI060507; name: SENY Fundació Research, award: 2005-0308007; name: Fundación Marqués de Valdecilla, award: API07/011
- Language
- English
- Date published
- 03/30/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003488002771
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