Shape-directed compartmentalized delivery of a nanoparticle-conjugated small-molecule activator of an epigenetic enzyme in the brain

Piyush Chaturbedy; Manoj Kumar; Krishnachary Salikolimi; Sadhan Das; Sarmistha Halder Sinha; Snehajyoti Chatterjee; B. S. Suma; Tapas K. Kundu; Muthusamy Eswaramoorthy

doi:10.1016/j.jconrel.2015.08.043

Back

Shape-directed compartmentalized delivery of a nanoparticle-conjugated small-molecule activator of an epigenetic enzyme in the brain

Journal article

Peer reviewed

Shape-directed compartmentalized delivery of a nanoparticle-conjugated small-molecule activator of an epigenetic enzyme in the brain

Piyush Chaturbedy, Manoj Kumar, Krishnachary Salikolimi, Sadhan Das, Sarmistha Halder Sinha, Snehajyoti Chatterjee, B. S. Suma, Tapas K. Kundu and Muthusamy Eswaramoorthy

Journal of controlled release, Vol.217, pp.151-159

11/10/2015

DOI: 10.1016/j.jconrel.2015.08.043

PMID: 26325406

View Online

Abstract

Targeted drug delivery to specific subcellular compartments of brain cells is challenging despite their importance in the treatment of several brain-related diseases. Herein, we report on shape-directed intracellular compartmentalization of nanoparticles in brain cells and their ability to deliver therapeutic molecules to specific organelles. Iron oxide (Fe3O4) nanoparticles with different morphologies (spheres, spindles, biconcaves, and nanotubes) were synthesized and coated with a fluorescent carbon layer derived from glucose (Fe3O4@C). In vivo studies showed that the Fe3O4@C nanoparticles with biconcave geometry localized predominantly in the nuclei of the brain cells, whereas those with nanotube geometry were contained mostly in the cytoplasm. Remarkably, a small-molecule activator of histone acetyltransferases delivered into the nuclei of the brain cells using nanoparticles with biconcave geometry showed enhancement in enzymatic activity by a factor of three and resulted in specific gene expression (transcription) compared with that of the molecule delivered to the cytoplasm using nanotube geometry. (c) 2015 Elsevier B.V. All rights reserved.

Physical Sciences

Chemistry

Chemistry, Multidisciplinary

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Science & Technology

Details

Title: Subtitle: Shape-directed compartmentalized delivery of a nanoparticle-conjugated small-molecule activator of an epigenetic enzyme in the brain
Creators: Piyush Chaturbedy - Jawaharlal Nehru Centre for Advanced Scientific Research
Manoj Kumar - Jawaharlal Nehru Centre for Advanced Scientific Research
Krishnachary Salikolimi - Jawaharlal Nehru Centre for Advanced Scientific Research
Sadhan Das - Jawaharlal Nehru Centre for Advanced Scientific Research
Sarmistha Halder Sinha - Jawaharlal Nehru Centre for Advanced Scientific Research
Snehajyoti Chatterjee - Jawaharlal Nehru Centre for Advanced Scientific Research
B. S. Suma - Jawaharlal Nehru Centre for Advanced Scientific Research
Tapas K. Kundu - Jawaharlal Nehru Centre for Advanced Scientific Research
Muthusamy Eswaramoorthy - Jawaharlal Nehru Centre for Advanced Scientific Research
Resource Type: Journal article
Publication Details: Journal of controlled release, Vol.217, pp.151-159
DOI: 10.1016/j.jconrel.2015.08.043
PMID: 26325406
NLM abbreviation: J Control Release
ISSN: 0168-3659
eISSN: 1873-4995
Publisher: Elsevier
Number of pages: 9
Grant note: name: Department of Biotechnology, the Government of India, award: /DBT/PR3018/NNT/28/544/2011; name: Indo-French Centre for the Promotion of Advanced Research-CEFIPRA, award: /IFC/4803-3/2012/1139; DOI: 10.13039/501100005116, name: JNCASR
Language: English
Date published: 11/10/2015
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984303854002771

Metrics

8 Record Views

25 Times Cited - Web of Science

See more details