Journal article
Shaping and reshaping CD8+ T-cell memory
Nature reviews. Immunology, Vol.8(2), pp.107-119
02/2008
DOI: 10.1038/nri2251
PMID: 18219309
Abstract
The ability to develop and sustain populations of memory T cells after infection or immunization is a hallmark of the adaptive immune response and a basis for protective vaccination against infectious disease. Technical advances that allow direct ex vivo identification and characterization of antigen-specific CD8+ T cells at various stages of the response to infection or vaccination in mouse models have fuelled efforts to characterize the factors that control memory CD8+ T-cell generation. Here, we dissect the input signals that shape the characteristics of the memory CD8+ T-cell response and discuss how manipulation of these signals has the potential to reshape CD8+ T-cell memory and improve the efficacy of vaccination.
Details
- Title: Subtitle
- Shaping and reshaping CD8+ T-cell memory
- Creators
- John T Harty - Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, USA. john-harty@uiowa.eduVladimir P Badovinac
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Immunology, Vol.8(2), pp.107-119
- Publisher
- England
- DOI
- 10.1038/nri2251
- PMID
- 18219309
- ISSN
- 1474-1733
- eISSN
- 1474-1741
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047874902771
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