Journal article
Shared and independent roles of CGRP and PACAP in migraine pathophysiology
Journal of headache and pain, Vol.24(1), 34
04/03/2023
DOI: 10.1186/s10194-023-01569-2
PMCID: PMC10069045
PMID: 37009867
Abstract
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) have emerged as mediators of migraine pathogenesis. Both are vasodilatory peptides that can cause migraine-like attacks when infused into people and migraine-like symptoms when injected into rodents. In this narrative review, we compare the similarities and differences between the peptides in both their clinical and preclinical migraine actions. A notable clinical difference is that PACAP, but not CGRP, causes premonitory-like symptoms in patients. Both peptides are found in distinct, but overlapping areas relevant to migraine, most notably with the prevalence of CGRP in trigeminal ganglia and PACAP in sphenopalatine ganglia. In rodents, the two peptides share activities, including vasodilation, neurogenic inflammation, and nociception. Most strikingly, CGRP and PACAP cause similar migraine-like symptoms in rodents that are manifested as light aversion and tactile allodynia. Yet, the peptides appear to act by independent mechanisms possibly by distinct intracellular signaling pathways. The complexity of these signaling pathways is magnified by the existence of multiple CGRP and PACAP receptors that may contribute to migraine pathogenesis. Based on these differences, we suggest PACAP and its receptors provide a rich set of targets to complement and augment the current CGRP-based migraine therapeutics.
Details
- Title: Subtitle
- Shared and independent roles of CGRP and PACAP in migraine pathophysiology
- Creators
- Adisa Kuburas - Iowa City, IA 52242 USAAndrew F. Russo - Iowa City, IA 52242 USA Iowa City, IA 52246 USA
- Resource Type
- Journal article
- Publication Details
- Journal of headache and pain, Vol.24(1), 34
- DOI
- 10.1186/s10194-023-01569-2
- PMID
- 37009867
- PMCID
- PMC10069045
- NLM abbreviation
- J Headache Pain
- ISSN
- 1129-2369
- eISSN
- 1129-2377
- Publisher
- Springer Milan
- Grant note
- I01 RX003523-01 / ; RF1 NS113839; R01 NS075599 / ;
- Language
- English
- Date published
- 04/03/2023
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984384309302771
Metrics
18 Record Views