Shared barriers and facilitators to enrollment of adolescents and young adults on cancer clinical trials

Nupur Mittal; Aniket Saha; Viswatej Avutu; Varun Monga; David R Freyer; Michael Roth

doi:10.1038/s41598-022-07703-5

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Shared barriers and facilitators to enrollment of adolescents and young adults on cancer clinical trials

Journal article

Open access

Peer reviewed

Shared barriers and facilitators to enrollment of adolescents and young adults on cancer clinical trials

Nupur Mittal, Aniket Saha, Viswatej Avutu, Varun Monga, David R Freyer and Michael Roth

Scientific reports, Vol.12(1), pp.3875-3875

03/09/2022

DOI: 10.1038/s41598-022-07703-5

PMCID: PMC8907177

PMID: 35264642

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https://doi.org/10.1038/s41598-022-07703-5View

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Abstract

Adolescent and young adult (AYA) enrollment in cancer clinical trials (CCT) is suboptimal. Few studies have explored site level barriers and facilitators to AYA enrollment on CCTs and the efficacy of interventions to enhance enrollment. A cross sectional survey was developed by the COG AYA Oncology Discipline Committee Responsible Investigator (RI) Network to identify perceived barriers and facilitators to enrollment, as well as opportunities to improve enrollment. Associations of barriers and facilitators to enrollment with program demographics were assessed. The survey was sent to all AYA RI Network members (n = 143) and quantitative and thematic analyses were conducted. The overall response rate was 42% (n = 60/143). Participants represented diverse institutions based on size, presence or absence of dedicated AYA programs, and proximity and relationship between pediatric and medical oncology practices within the institution. The most frequently cited barriers to enrolling AYAs in CCTs were administrative logistical issues (45%), disparate enrollment practices (42%) and communication issues (27%) between pediatric and medical oncology and perceived limited trial availability (27%). The most frequently reported facilitators to enrollment included having strong communication between pediatric and medical oncology (48%), having a supportive research infrastructure (35%) and the presence of AYA champions (33%). Many barriers and facilitators were similar across institutions and AYA program types. Shared barriers and facilitators to AYA CCT enrollment exist across the landscape of cancer care settings. Interventions aimed at increasing coordination between pediatric and medical oncology clinical trials offices and providers have high potential to improve site-level AYA enrollment.

Adolescent

Child

Clinical Trials as Topic

Communication

Cross-Sectional Studies

Humans

Medical Oncology

Neoplasms - therapy

Patient Selection

Young Adult

Details

Title: Subtitle: Shared barriers and facilitators to enrollment of adolescents and young adults on cancer clinical trials
Creators: Nupur Mittal - Rush University Medical Center
Aniket Saha - Prisma Health
Viswatej Avutu - Memorial Sloan Kettering Cancer Center
Varun Monga - University of Iowa
David R Freyer - University of Southern California
Michael Roth - The University of Texas MD Anderson Cancer Center
Resource Type: Journal article
Publication Details: Scientific reports, Vol.12(1), pp.3875-3875
DOI: 10.1038/s41598-022-07703-5
PMID: 35264642
PMCID: PMC8907177
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Grant note: P30 CA008748 / NCI NIH HHS U10 CA180886 / NCI NIH HHS P30 CA016672 / NCI NIH HHS
Language: English
Date published: 03/09/2022
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984359681802771

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