Journal article
Shared deficits of education, marital and occupational functioning in unaffected siblings of multiple affected families with major psychiatric illness
Asian journal of psychiatry, Vol.101, p.104216
11/01/2024
DOI: 10.1016/j.ajp.2024.104216
PMID: 39243658
Abstract
Background: Major psychiatric illnesses often cluster in families, and their impact on affected and unaffected members within families may reflect the consequence of both genetic and social liability. Methods: Data was derived from 202 families with multiple affected individuals. Affected individuals (N = 259) had a diagnosis of schizophrenia, bipolar disorder, obsessive-compulsive disorder or substance use disorder. For comparison, we used the unaffected siblings from the same families (N = 229) and a matched random subset of healthy control (HC) data (N = 229) from India's National Mental Health Survey, 2016 (NMHS). We compared the three groups' educational attainment, functional marital status, and occupational status. Results: The highest educational attainment was significantly different between the groups. The affected and unaffected siblings had poorer educational attainment compared to HC. Similarly, the affected and unaffected siblings more often remained single, in contrast to HC. Moreover, employment rates were significantly higher in the unaffected siblings, especially female siblings. Overall, females had spent fewer years at school, were primarily married, and were majority homemakers across the three groups compared to males. Discussion: Affected and unaffected siblings had lower education and marriage rates than HC. The unaffected siblings were more likely to be employed than HC. Whether the poor educational attainment and lower marriage rates in unaffected siblings is a biological marker of shared endophenotype or the effect of the social burden of having an affected family member requires further systematic evaluation.
Details
- Title: Subtitle
- Shared deficits of education, marital and occupational functioning in unaffected siblings of multiple affected families with major psychiatric illness
- Creators
- Moorthy Muthukumaran - National Institute of Mental Health and NeurosciencesSowmya Selvaraj - National Institute of Mental Health and NeurosciencesSrinivas Balachander - National Institute of Mental Health and NeurosciencesRavi Kumar Nadella - National Institute of Mental Health and NeurosciencesVanteemar S. Sreeraj - National Institute of Mental Health and NeurosciencesPavithra Jayasankar - National Institute of Mental Health and NeurosciencesSwarna Buddha Nayok - National Institute of Mental Health and NeurosciencesSreenivasulu Mullappagari - National Institute of Mental Health and NeurosciencesShruthi Narayan - National Institute of Mental Health and NeurosciencesPramod Kumar - National Institute of Mental Health and NeurosciencesAnand Jose Kannampuzha - National Institute of Mental Health and NeurosciencesAlen Chandy Alexander - National Institute of Mental Health and NeurosciencesPavithra Dayalamurthy - National Institute of Mental Health and NeurosciencesMahashweta Bhattacharya - National Institute of Mental Health and NeurosciencesMino Susan Joseph - National Institute of Mental Health and NeurosciencesSweta Sheth - National Institute of Mental Health and NeurosciencesJoan C. Puzhakkal - National Institute of Mental Health and NeurosciencesNavya Spurthi Thatikonda - National Institute of Mental Health and NeurosciencesDhruva Ithal - National Institute of Mental Health and NeurosciencesBiju Viswanath - National Institute of Mental Health and NeurosciencesSydney Moirangthem - National Institute of Mental Health and NeurosciencesGanesan Venkatasubramanian - National Institute of Mental Health and NeurosciencesJohn P. John - National Institute of Mental Health and NeurosciencesJagadisha Thirthalli - National Institute of Mental Health and NeurosciencesY. C. Janardhan Reddy - National Institute of Mental Health and NeurosciencesVivek Benegal - National Institute of Mental Health and NeurosciencesMathew Varghese - National Institute of Mental Health and NeurosciencesSanjeev Jain - National Institute of Mental Health and NeurosciencesADBS Consortium
- Resource Type
- Journal article
- Publication Details
- Asian journal of psychiatry, Vol.101, p.104216
- Publisher
- Elsevier
- DOI
- 10.1016/j.ajp.2024.104216
- PMID
- 39243658
- ISSN
- 1876-2018
- eISSN
- 1876-2026
- Number of pages
- 6
- Grant note
- BT/PR17316/MED/31/326/2015 / Accelerator program for Discovery in Brain disorders using Stem cells (ADBS) Centre for Brain and Mind (CBM) grant of the Rohini Nilekani Philanthropies IA/CPHI/20/1/505266 / Intermediate (Clinical and Public Health) Fellowship of the DBT/Wellcome Trust India Alliance; Wellcome Trust
- Language
- English
- Date published
- 11/01/2024
- Academic Unit
- Psychiatry
- Record Identifier
- 9984843605602771
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