Journal article
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Addiction biology, Vol.40(1), pp.e12880-n/a
02/16/2020
DOI: 10.1111/adb.12880
PMCID: PMC7429266
PMID: 32064741
Abstract
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
Details
- Title: Subtitle
- Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
- Creators
- Melissa Munn-Chernoff - University of North Carolina at Chapel HillEmma Johnson - Washington University in St. LouisYi-Ling Chou - Washington University in St. LouisJonathan R.I. Coleman - King's College LondonLaura Thornton - University of North Carolina at Chapel HillRaymond Walters - Massachusetts Institute of TechnologyZeynep Yilmaz - University of North Carolina at Chapel HillJessica Baker - University of North Carolina at Chapel HillChristopher Hübel - Karolinska InstitutetScott Gordon - QIMR Berghofer Medical Research InstituteSarah Medland - QIMR Berghofer Medical Research InstituteHunna Watson - University of North Carolina at Chapel HillHéléna Gaspar - King's College LondonJulien Bryois - Karolinska InstitutetAnke Hinney - University of Duisburg-EssenVirpi Leppä - Karolinska InstitutetManuel Mattheisen - Aarhus UniversityStephan Ripke - Charité - Universitätsmedizin BerlinShuyang Yao - Karolinska InstitutetPaola Giusti-Rodríguez - University of North Carolina at Chapel HillKen Hanscombe - King's College LondonRoger A.H. Adan - Utrecht UniversityLars Alfredsson - Karolinska InstitutetTetsuya Ando - National Institute of Mental HealthOle Andreassen - University of OsloWade Berrettini - University of PennsylvaniaIlka Boehm - Technische Universität DresdenClaudette Boni - InsermVesna Boraska Perica - University of SplitKatharina Buehren - RWTH Aachen UniversityRoland Burghardt - Universitätsklinikum FrankfurtMatteo Cassina - University of PaduaSven Cichon - University of BaselMaurizio Clementi - University of PaduaRoger Cone - University of MichiganPhilippe Courtet - Université de MontpellierScott Crow - University of MinnesotaJames Crowley - Karolinska InstitutetUnna Danner - Altrecht Center for Eating Disorders Rintveld [Zeist, The Netherlands]Oliver S.P. Davis - University of BristolMartina de Zwaan - Medizinische Hochschule HannoverGeorge Dedoussis - Harokopio University of AthensDaniela Degortes - University of PaduaJaniece Desocio - Seattle UniversityDanielle Dick - Virginia Commonwealth UniversityDimitris Dikeos - Athens State UniversityChristian Dina - Nantes UniversitéMonika Dmitrzak-Weglarz - Poznan University of Medical SciencesElisa Docampo - Universitat Pompeu FabraLaramie Duncan - Stanford UniversityKarin Egberts - University of WürzburgStefan Ehrlich - Technische Universität DresdenGeòrgia Escaramís - Universitat Pompeu FabraTõnu Esko - University of TartuXavier Estivill - Universitat Pompeu FabraAnne Farmer - King's College LondonAngela Favaro - University of PaduaFernando Fernández-Aranda - Universitat de BarcelonaManfred Fichter - Ludwig-Maximilians-Universität MünchenKrista Fischer - University of TartuManuel Föcker - University of MünsterLenka Foretova - Masaryk Memorial Cancer InstituteAndreas Forstner - University of BaselMonica Forzan - University of PaduaChristopher Franklin - Wellcome Sanger InstituteSteven Gallinger - University of TorontoIna Giegling - Martin Luther University Halle-WittenbergJohanna Giuranna - University of Duisburg-EssenFragiskos Gonidakis - National and Kapodistrian University of AthensPhilip Gorwood - Délégation Paris 5Monica Gratacos Mayora - Institute of Environmental Science and Technology [Barcelona]Sébastien Guillaume - Université de MontpellierYiran Guo - University of PennsylvaniaHakon Hakonarson - University of PennsylvaniaKonstantinos Hatzikotoulas - Wellcome Sanger InstituteJoanna Hauser - Psychiatric Genetic UnitJohannes Hebebrand - University of Duisburg-EssenSietske Helder - King's College LondonStefan Herms - University of BaselBeate Herpertz-Dahlmann - RWTH Aachen UniversityWolfgang Herzog - Heidelberg UniversityLaura Huckins - Icahn School of Medicine at Mount SinaiJames Hudson - Harvard UniversityHartmut Imgart - Parkland-Klinik [Bad Wildungen-Reinhardshausen, Germany]Hidetoshi Inoko - Tokai UniversityVladimír Janout - Department of Epidemiology and Public Health [university of Ostrava]Susana Jiménez-Murcia - Universitat de BarcelonaAntonio Julià - Hebron UniversityGursharan Kalsi - King's College LondonDeborah Kaminská - Charles UniversityLeila Karhunen - University of Eastern FinlandAndreas Karwautz - Medical University of ViennaMartien J.H. Kas - University of GroningenJames Kennedy - University of TorontoAnna Keski-Rahkonen - University of HelsinkiKirsty Kiezebrink - University of AberdeenYoul-Ri Kim - Inje UniversityKelly Klump - Michigan State UniversityGun Peggy S. Knudsen - Norwegian Institute of Public HealthMaria La Via - University of North Carolina at Chapel HillSamuel Kuperman - Psychiatry
- Resource Type
- Journal article
- Publication Details
- Addiction biology, Vol.40(1), pp.e12880-n/a
- DOI
- 10.1111/adb.12880
- PMID
- 32064741
- PMCID
- PMC7429266
- NLM abbreviation
- Addict Biol
- ISSN
- 1355-6215
- eISSN
- 1369-1600
- Publisher
- Wiley
- Language
- English
- Date published
- 02/16/2020
- Academic Unit
- Psychiatry
- Record Identifier
- 9984293753102771
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