Journal article
Shifts in lifestyle and socioeconomic circumstances predict change—for better or worse—in speed of epigenetic aging: A study of middle-aged black women
Social science & medicine (1982), Vol.307, 115175
08/2022
DOI: 10.1016/j.socscimed.2022.115175
PMID: 35820233
Abstract
While numerous studies have documented the power of new generation epigenetic clocks to predict morbidity and mortality, research regarding the causes of variation in speed of epigenetic aging is in the early stages. To the extent that these epigenetic clocks are robust measures of biological aging, they should be sensitive to various nutritional, behavioral, ecological, and social factors that have been shown to affect health.
Investigate over an 11-year period the extent to which changes in socioeconomic stress and lifestyle predict changes in speed of epigenetic aging among a sample of middle-aged African American women.
Using data from the Family and Community Health Study, we investigated whether changes in socioeconomic stress, diet, smoking, exercise, alcohol consumption, and relationship status predict changes in speed of biological aging assessed with 3 s-generation epigenetic clocks: AccelGrimAge, DunedinPoAm, and AccelPhenoAge. The study was able to avoid the challenges associated with self-reports of diet and smoking by employing recently developed epigenetic measures.
Changes in socioeconomic stress and diet were associated with changes in speed of biological aging as assessed by all three epigenetic clocks, and changes in smoking was related to changes in AccelGrimAge and DunedinPoAm. Analyses controlling for cell-type indicated that in large measure diet exerts its effect on aging through its impact on the immune system.
These findings suggest that adoption of a healthy diet and reduction in the use of tobacco are related to a decrease in epigenetic aging, whereas increased pressure relating to income, housing and economic independence are associated with an increase in the speed of aging. These effects were especially strong for the two epigenetic clocks AccelGrimAge and DunedinPoAm. Overall, the results indicate that stress and lifestyle changes may, for better or worse, influence the “biological weathering” often experienced by middle-aged African American women.
•Changes in stress and lifestyle predicted changes in speed of aging.•Speed of aging was assessed using three new generation epigenetic clocks.•Increases in socioeconomic stress and smoking increased speed of aging.•Switching to a more nutritious diet reduced speed of aging.•Epigenetic clocks might be used as surrogates for morbidity and mortality.
Details
- Title: Subtitle
- Shifts in lifestyle and socioeconomic circumstances predict change—for better or worse—in speed of epigenetic aging: A study of middle-aged black women
- Creators
- Ronald L. Simons - University of GeorgiaMei Ling Ong - Center for Family Research, University of Georgia, United StatesMan-Kit Lei - Department of Sociology, University of Georgia, Athens, GA, 30602, United StatesEric Klopach - Leonard-Davis School of Gerontology, University of Southern California, United StatesMark Berg - Department of Sociology, University of Iowa, United StatesYue Zhang - University of GeorgiaRobert Philibert - College of Medicine, University of Iowa, United StatesFrederick X. Gibbons - Department of Psychological Sciences, University of Connecticut, United StatesSteven R.H. Beach - University of Georgia
- Resource Type
- Journal article
- Publication Details
- Social science & medicine (1982), Vol.307, 115175
- DOI
- 10.1016/j.socscimed.2022.115175
- PMID
- 35820233
- NLM abbreviation
- Soc Sci Med
- ISSN
- 0277-9536
- eISSN
- 1873-5347
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: R21 DA034457; DOI: 10.13039/100000049, name: National Institute on Aging, award: R01 AG055393, RF 1AG077386; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01 HL118045; DOI: 10.13039/100000071, name: National Institute of Child Health and Human Development; DOI: 10.13039/100009633, name: Eunice Kennedy Shriver National Institute of Child Health and Human Development, award: R01 HD080749
- Language
- English
- Date published
- 08/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Sociology and Criminology; Iowa Neuroscience Institute; Center for Social Science Innovation; Injury Prevention Research Center; Public Policy Center (Archive)
- Record Identifier
- 9984282467302771
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