Journal article
Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe
Nature genetics, Vol.44(9), pp.1056-1059
08/05/2012
DOI: 10.1038/ng.2369
PMCID: PMC3442231
PMID: 22863732
Abstract
Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery(1,2), spreading efficiently via low-dose fecal-oral transmission(3,4). Historically, S. sonnei has been predominantly responsible for dysentery in developed countries but is now emerging as a problem in the developing world, seeming to replace the more diverse Shigella flexneri in areas undergoing economic development and improvements in water quality(4-6). Classical approaches have shown that S. sonnei is genetically conserved and clonal(7). We report here whole-genome sequencing of 132 globally distributed isolates. Our phylogenetic analysis shows that the current S. sonnei population descends from a common ancestor that existed less than 500 years ago and that diversified into several distinct lineages with unique characteristics. Our analysis suggests that the majority of this diversification occurred in Europe and was followed by more recent establishment of local pathogen populations on other continents, predominantly due to the pandemic spread of a single, rapidly evolving, multidrug-resistant lineage.
Details
- Title: Subtitle
- Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe
- Creators
- Kathryn E Holt - University of MelbourneStephen Baker - Oxford University Clinical Research Unit [Ho Chi Minh City]François-Xavier Weill - Bactéries pathogènes entériquesEdward C Holmes - National Institutes of Health [Bethesda]Andrew Kitchen - The Pennsylvannia State UniversityJun Yu - University of StrathclydeVartul SangalDerek J Brown - Stobhill HospitalJohn E Coia - Stobhill HospitalDong-Wook Kim - Hanyang UniversityChoi Seon Young - International Vaccine InstituteSu Hee Kim - International Vaccine InstituteWanderley Dias Da Silveira - University of Campinas [Campinas]Derek Pickard - The Wellcome Trust Sanger Institute [Cambridge]Jeremy J Farrar - Oxford University Clinical Research Unit [Ho Chi Minh City]Julian Parkhill - The Wellcome Trust Sanger Institute [Cambridge]Gordon Dougan - The Wellcome Trust Sanger Institute [Cambridge]Nicholas R Thomson - The Wellcome Trust Sanger Institute [Cambridge]
- Contributors
- Marie Lemesle (Editor)
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.44(9), pp.1056-1059
- DOI
- 10.1038/ng.2369
- PMID
- 22863732
- PMCID
- PMC3442231
- NLM abbreviation
- Nat Genet
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Publisher
- Nature Publishing Group
- Language
- English
- Date published
- 08/05/2012
- Academic Unit
- Anthropology; International Programs
- Record Identifier
- 9983983645402771
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