Journal article
Short Physical Performance Battery and Incident Cardiovascular Events Among Older Women
Journal of the American Heart Association, Vol.9(14), pp.e016845-e016845
07/21/2020
DOI: 10.1161/JAHA.120.016845
PMCID: PMC7660732
PMID: 32662311
Abstract
Background The Short Physical Performance Battery (SPPB) is an inexpensive, reliable, and easy-to-implement measure of lower-extremity physical function. Strong evidence links SPPB scores with all-cause mortality, but little is known about its relationship with incident cardiovascular disease (CVD). Methods and Results Women (n=5043, mean age=79±7) with no history of myocardial infarction or stroke completed 3 timed assessments-standing balance, strength (5 chair stands), and usual gait speed (4 m walk)-yielding an SPPB score from 0 (worst) to 12 (best). Women were followed for CVD events (myocardial infarction, stroke, or CVD death) up to 6 years. Hazard ratios were estimated for women with
(0-3),
(4-6),
(7-9), and
(10-12) SPPB scores using Cox proportional hazard models adjusted for demographic, behavioral, and health-related variables including objective measurements of physical activity, blood pressure, lipids, and glucose levels. Restricted cubic splines tested linearity of associations. With 361 CVD cases, crude incidence rates/1000 person-years were 41.0, 24.3, 16.1, and 8.6 for
,
,
and
SPPB categories, respectively. Corresponding fully adjusted hazard ratios (95% CIs) were 2.28 (1.50-3.48), 1.70 (1.23-2.36) 1.49 (1.12-1.98), and 1.00 (referent);
-trend <0.001. The dose-response relationship was linear (linear
<0.001; nonlinear
>0.38). Conclusions Results suggest SPPB may provide a measure of cardiovascular health in older adults beyond that captured by traditional risk factors. Because of its high test-retest reliability and low administrative burden, the SPPB should be a routine part of office-based CVD risk assessment.
Details
- Title: Subtitle
- Short Physical Performance Battery and Incident Cardiovascular Events Among Older Women
- Creators
- John Bellettiere - Center for Behavioral Epidemiology and Community Health (C-BEACH) San Diego State University San Diego CAMichael J Lamonte - Department of Epidemiology and Environmental Health School of Public Health and Health Professions University at Buffalo-SUNY Buffalo NYJonathan Unkart - Department of Family Medicine and Public Health University of California San Diego La Jolla CASandy Liles - Center for Behavioral Epidemiology and Community Health (C-BEACH) San Diego State University San Diego CADeepika Laddu-Patel - College of Applied Health Sciences University of Illinois Chicago ILJoAnn E Manson - Division of Preventive Medicine Brigham and Women's Hospital Harvard Medical School Boston MAHailey Banack - Department of Epidemiology and Environmental Health School of Public Health and Health Professions University at Buffalo-SUNY Buffalo NYRebecca Seguin-Fowler - Department of Nutrition and Food Science College of Agriculture and Life Sciences Texas A&M University College Station TXPaul Chavez - Department of Family Medicine and Public Health University of California San Diego La Jolla CALesley F Tinker - Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WARobert B Wallace - College of Public Health University of Iowa Iowa City IAAndrea Z LaCroix - Department of Family Medicine and Public Health University of California San Diego La Jolla CA
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.9(14), pp.e016845-e016845
- DOI
- 10.1161/JAHA.120.016845
- PMID
- 32662311
- PMCID
- PMC7660732
- NLM abbreviation
- J Am Heart Assoc
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Publisher
- England
- Grant note
- HHSN268201600018C / NHLBI NIH HHS K01 HL148503 / NHLBI NIH HHS R01 HL105065 / NHLBI NIH HHS HHSN268201600003C / NHLBI NIH HHS HHSN268201600004C / NHLBI NIH HHS P01 AG052352 / NIA NIH HHS HHSN268201600002C / NHLBI NIH HHS HHSN268201600001C / NHLBI NIH HHS T32 HL079891 / NHLBI NIH HHS
- Language
- English
- Date published
- 07/21/2020
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984066333902771
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