Journal article
Short-Term Omeprazole Use Does Not Affect Serum Calcium Concentrations and Bone Density in Horses
Journal of equine veterinary science, Vol.35(9), pp.714-723
09/01/2015
DOI: 10.1016/j.jevs.2015.07.003
Abstract
Omeprazole is used to treat gastric ulcers in horses. In some human and experimental animal studies, proton pump inhibitor use has been associated with a change in bone density or fracture risk. This study evaluated the effects of administration of omeprazole for 60 days and its effects on serum total calcium, ionized serum calcium, bone mineral content (BMC), and bone mineral density (BMD) in horses. Blood samples and bone biopsies from the tibia were collected from 10 geldings aged 2 and 3 years old before beginning treatment. Horses were administered either 4 mg/kg omeprazole paste or an equal volume of vehicle only paste orally once per day for 60 days. Blood samples were taken at days 7, 14, 21, 28, 35, 42, 49, 56, and 60. Serum total calcium and ionized calcium were measured on all samples. Horses were euthanized on day 60, and bone was harvested from all horses from the contralateral tibia. In addition, the third metacarpal bones and proximal femurs were harvested from each subject. Bone samples were evaluated for BMD and BMC using peripheral quantitative computed tomography (pQCT). Serum total calcium and ionized calcium concentrations were not significantly different between treated and control groups. Bone density and composition were also not significantly different when compared between control and treatment groups. Short-term administration of omeprazole does not significantly affect serum total calcium and ionized serum calcium concentrations nor does it affect bone density or BMC in normal horses as measured with pQCT.
•The effects of omeprazole administration on serum calcium and bone mineral density are investigated.•Treated and control groups did not differ significantly after 60 days of omeprazole or placebo.•Omeprazole did not significantly affect serum calcium or bone density in normal adult horses.
Details
- Title: Subtitle
- Short-Term Omeprazole Use Does Not Affect Serum Calcium Concentrations and Bone Density in Horses
- Creators
- Stephanie S. Caston - Iowa State UniversityDouglas C. Fredericks - University of IowaKevin D. Kersh - Iowa State UniversityChong Wang - Iowa State University
- Resource Type
- Journal article
- Publication Details
- Journal of equine veterinary science, Vol.35(9), pp.714-723
- DOI
- 10.1016/j.jevs.2015.07.003
- ISSN
- 0737-0806
- eISSN
- 1542-7412
- Publisher
- Elsevier Inc
- Number of pages
- 10
- Language
- English
- Date published
- 09/01/2015
- Academic Unit
- Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center
- Record Identifier
- 9985034982102771
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