Short-term bone responses to hydroxyapatite cement

Dominic Morio; Daniel Lew; Kenneth Krizan; John C Keller

doi:10.1097/00008505-200211040-00018

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Short-term bone responses to hydroxyapatite cement

Journal article

Open access

Peer reviewed

Short-term bone responses to hydroxyapatite cement

Dominic Morio, Daniel Lew, Kenneth Krizan and John C Keller

Implant dentistry, Vol.11(4), pp.376-382

2002

DOI: 10.1097/00008505-200211040-00018

PMID: 12518706

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Abstract

The purpose of this study was to evaluate the short-term wound healing and repair at the tissue/cement interface with different hydroxyapatite cement formulations. Three groups of Sprague-Dawley rats were implanted with HAC for 3, 7, or 14 days. The medial femur-tibia sites on each leg of the animals were used to create four separate 1.5-mm defects, which were filled with HAC (Bone-Source, Howmedica-Leibinger, Inc.) mixed with either water (W) as a control, an accelerant (0.1 M sodium phosphate, SP), or a stabilizer (1% hydroxypropylmethyl cellulose, HPMC) as diluents. At the appropriate postimplantation times, the animals were euthanized and tissue-implant blocks were prepared for qualitative histopathologic evaluations. Osseoconduction around and into the HAC was observed with all three cement formulations and the control (unfilled) site by day 7 and continued through day 14. The histologic staining did not reveal resorption lacunae or other cellular activities characteristic of osteoclast degradation of HAC. These results suggests that other processes, perhaps physical-chemical in nature, contributed to the initial degradation of the HAC following surgical placement. Structural stability of HAC was noted when using HPMC as the diluent. However, when either W or SP were employed, dissociation (washout) of the HAC into the surrounding tissue was noted. HAC is prone to in situ physical-chemical breakdown before the completion of the setting reaction. Diluents designed to stabilize or accelerate the HAC mixture appeared to improve the handling properties of the HAC without compromising the biological characteristics of the cement.

Bone and Bones - pathology

Osteotomy

Biocompatible Materials - chemistry

Coloring Agents

Phosphates - chemistry

Methylcellulose - analogs & derivatives

Bone and Bones - drug effects

Excipients - chemistry

Time Factors

Durapatite - pharmacology

Water - chemistry

Models, Animal

Bone Cements - chemistry

Wound Healing - drug effects

Bone Regeneration - drug effects

Osteogenesis - drug effects

Rats

Durapatite - chemistry

Biocompatible Materials - pharmacology

Rats, Sprague-Dawley

Chemistry, Pharmaceutical

Absorbable Implants

Methylcellulose - chemistry

Animals

Bone Cements - pharmacology

Hypromellose Derivatives

Details

Title: Subtitle: Short-term bone responses to hydroxyapatite cement
Creators: Dominic Morio - Department of Oral and Maxillofacial Surgery, University of Iowa, Iowa City, IA, USA
Daniel Lew
Kenneth Krizan
John C Keller
Resource Type: Journal article
Publication Details: Implant dentistry, Vol.11(4), pp.376-382
Publisher: United States
DOI: 10.1097/00008505-200211040-00018
PMID: 12518706
ISSN: 1056-6163
eISSN: 1538-2982
Grant note: P60 DE13076 / NIDCR NIH HHS
Language: English
Date published: 2002
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Graduate College Admin and Gen; President; Oral and Maxillofacial Surgery; Dental Research; Hospital Dentistry
Record Identifier: 9984066095202771

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