Journal article
Short-term fluoxetine treatment enhances baroreflex control of sympathetic nervous system activity after hindlimb unloading
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.286(3), pp.R584-590
03/2004
DOI: 10.1152/ajpregu.00223.2002
PMID: 14761868
Abstract
Data in humans indicate that individuals with orthostatic hypotension that are refractory to other traditional forms of therapy are responsive to selective serotonin reuptake inhibitor (SSRI) treatment. We tested the hypothesis that SSRI administration would help correct the attenuated baroreflex control of sympathetic nervous system activity in the hindlimb-unloaded (HU) rat model of cardiovascular deconditioning. An initial study was conducted to determine the time course of effects of fluoxetine (Flu) administration on baroreflex control of lumbar sympathetic nerve activity (LSNA) in conscious, chronically instrumented rats. Animals received either vehicle (Veh, sterile water) or 10 mg/kg Flu for 1, 4, or 16 days of treatment. Data indicate that while 1-day and 16-day Flu administration did not affect baroreflex function, baroreflex control of LSNA was enhanced after 4-day (short term) Flu administration. HU rats were then treated with Flu for 4 days and compared with HU rats receiving Veh and to casted control rats maintained in the normal posture that received either Veh or short-term Flu treatment. Similar to pilot data, short-term Flu treatment enhanced baroreflex control of LSNA in both HU rats and control rats. These data taken together indicate that baroreflex control of sympathetic nervous system activity is a possible mechanism responsible for the successful treatment of orthostatic intolerance with Flu.
Details
- Title: Subtitle
- Short-term fluoxetine treatment enhances baroreflex control of sympathetic nervous system activity after hindlimb unloading
- Creators
- Julia A Moffitt - The Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242, USAAlan Kim Johnson
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.286(3), pp.R584-590
- DOI
- 10.1152/ajpregu.00223.2002
- PMID
- 14761868
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Grant note
- HL-07121 / NHLBI NIH HHS HL-14388 / NHLBI NIH HHS HL-57472 / NHLBI NIH HHS
- Language
- English
- Date published
- 03/2004
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984214757302771
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