Journal article
Short-term neurocognitive outcomes following anterior temporal lobectomy
Epilepsy & behavior, Vol.62, pp.140-146
09/2016
DOI: 10.1016/j.yebeh.2016.06.019
PMID: 27474963
Abstract
Changes in cognitive function are a well established risk of anterior temporal lobectomy (ATL). Deficits in verbal memory are a common postoperative finding, though a small proportion of patients may improve. Postoperative evaluation typically occurs after six to 12months. Patients may benefit from earlier evaluation to identify potential needs; however, the results of a formal neuropsychological assessment at an early postoperative stage are not described in the literature. We compared pre- and postoperative cognitive function for 28 right ATL and 23 left ATL patients using repeated measures ANOVA. Changes in cognitive function were compared to ILAE seizure outcome. The mean time to postoperative neuropsychological testing was 11.1weeks (SD=6.7weeks). There was a side×surgery interaction for the verbal tasks: immediate memory recall (F(1,33)=20.68, p<0.001), short delay recall (F(1,29)=4.99, p=0.03), long delay recall (F(1,33)=10.36, p=0.003), recognition (F(1,33)=5.69, p=0.02), and naming (F(1,37)=15.86, p<0.001). This indicated that the left ATL group had a significant decrement in verbal memory following surgery, while the right ATL group experienced a small but significant improvement. For the right ATL group, there was a positive correlation between ILAE outcome and improvement in immediate recall (r=−0.62, p=0.02) and long delay recall (r=−0.57, p=0.03). There was no similar finding for the left ATL group. This study demonstrates that short-interval follow-up is effective in elucidating postoperative cognitive changes. Right ATL was associated with improvement in verbal memory, while left ATL resulted in a decrement in performance. Improvement in the right ATL group was related to improved seizure outcome. Short-interval follow-up may lend itself to the identification of patients who could benefit from early intervention.
•Short-term neurocognitive follow-up can reveal both positive and negative outcomes.•Left ATL was associated with impairments in verbal memory.•Right ATL was associated with improvement in verbal memory.•Verbal improvement in right ATL was positively correlated with seizure improvement.
Details
- Title: Subtitle
- Short-term neurocognitive outcomes following anterior temporal lobectomy
- Creators
- Philip S. Lee - UPMC PresbyterianJamie Pardini - UPMC PresbyterianRick Hendrickson - University of Pittsburgh Medical CenterVincent Destefino - UPMC PresbyterianAlexandra Popescu - University of Pittsburgh Medical CenterGena Ghearing - University of Pittsburgh Medical CenterArun Antony - University of Pittsburgh Medical CenterJullie Pan - University of Pittsburgh Medical CenterAnto Bagic - University of Pittsburgh Medical CenterDanielle Wagner - UPMC PresbyterianR. Mark Richardson - UPMC Presbyterian
- Resource Type
- Journal article
- Publication Details
- Epilepsy & behavior, Vol.62, pp.140-146
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.yebeh.2016.06.019
- PMID
- 27474963
- ISSN
- 1525-5050
- eISSN
- 1525-5069
- Grant note
- DOI: 10.13039/100000945, name: Pittsburgh Foundation, award: UN2014-73622
- Language
- English
- Date published
- 09/2016
- Academic Unit
- Neurology
- Record Identifier
- 9984303020002771
Metrics
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