Journal article
Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model
PLoS One, Vol.11(5), pp.0154857-0154857
05/04/2016
DOI: 10.1371/journal.pone.0154857
PMCID: PMC4856382
PMID: 27144769
Abstract
BACKGROUND: Hemophilia A animal models have helped advance our understanding of factor VIII deficiency. Previously, factor VIII deficient mouse models were reported to have a normal life span without spontaneous bleeds. However, the bleeding frequency and survival in these animals has not been thoroughly evaluated.
<p>OBJECTIVE: To investigate the survival and lethal bleeding frequency in two strains of E-16 hemophilia A mice.</p>
<p>METHODS: We prospectively studied factor VIII deficient hemizygous affected males (n = 83) and homozygous affected females (n = 55) for survival and bleeding frequency. Animals were evaluated for presence and location of bleeds as potential cause of death.</p>
<p>RESULTS AND CONCLUSIONS: Hemophilia A mice had a median survival of 254 days, which is significantly shortened compared to wild type controls (p < 0.0001). In addition, the hemophilia A mice experienced hemorrhage in several tissues. This previously-underappreciated shortened survival in the hemophilia A murine model provides new outcomes for investigation of therapeutics and also reflects the shortened lifespan of patients if left untreated.
Details
- Title: Subtitle
- Shortened Lifespan and Lethal Hemorrhage in a Hemophilia A Mouse Model
- Creators
- Janice M Staber - University of IowaMolly J Pollpeter
- Resource Type
- Journal article
- Publication Details
- PLoS One, Vol.11(5), pp.0154857-0154857
- DOI
- 10.1371/journal.pone.0154857
- PMID
- 27144769
- PMCID
- PMC4856382
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Number of pages
- 7
- Copyright
- Copyright © 2016 Staber, Pollpeter
- Grant note
- Grant ID: NIH HD027748-19
- Comment
This work was supported by the University of Iowa Children’s Miracle Network (JMS) and NIH HD027748-19, the Molecular and Cellular Research to Advance Child Health (JMS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
- Language
- English
- Date published
- 05/04/2016
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Hematology/Oncology
- Record Identifier
- 9983557354802771
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