Journal article
Should total thyroidectomy become the preferred procedure for surgical management of Graves' disease?
Thyroid (New York, N.Y.), Vol.15(6), pp.569-574
06/2005
DOI: 10.1089/thy.2005.15.569
PMID: 16029123
Abstract
This study aims to evaluate our institution's experience with thyroidectomy for Graves' disease, with an emphasis on indications and long-term outcomes. The study cohort consisted of 103 patients (mean age 34.3 [+/-13.9] years), who underwent thyroidectomy for Graves' disease between 1991 and 2002. Clinical and follow-up data were obtained by retrospective review of medical records and by contacting treating physicians or patients. The most common surgical indications were patient preference (26%), cold nodule (24%), eye symptoms (20%), large goiter size (18%), allergy to antithyroidal medications (15%), and age younger than 16 years (14%). Thyroidectomies performed included 45 (total or near-total), 57 subtotal, and 1 lobectomy. Transient complications included hypocalcemia in 42 patients, and recurrent laryngeal nerve palsy in 5 patients. There was no difference in the frequency of hypocalcemia in patients undergoing total or subtotal resections. One patient developed permanent hypocalcemia and 2 permanent recurrent laryngeal nerve (RLN) injury. Only 3 patients who underwent subtotal resections remain off thyroxine and 2 developed recurrent hyperthyroidism approximately 17 and 54 months after surgery. Subtotal thyroidectomy is associated with a high rate of hypothyroidism and large remnants have potential for recurrence. Total or near-total thyroidectomy obviates these disadvantages and can be performed without increased complication rates, thus appearing to be the preferred extent of thyroidectomy for Graves' disease.
Details
- Title: Subtitle
- Should total thyroidectomy become the preferred procedure for surgical management of Graves' disease?
- Creators
- Geeta Lal - University of IowaPhilip ItuarteElectron Kebebew - University of California, San FranciscoAllan Siperstein - SurgeryQuan-Yang Duh - VA Medical CenterOrlo H Clark - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- Thyroid (New York, N.Y.), Vol.15(6), pp.569-574
- DOI
- 10.1089/thy.2005.15.569
- PMID
- 16029123
- ISSN
- 1050-7256
- eISSN
- 1557-9077
- Language
- English
- Date published
- 06/2005
- Academic Unit
- Stead Family Department of Pediatrics; Surgery
- Record Identifier
- 9984322939302771
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