Sialographic Analysis of Radioiodine-Associated Chronic Sialadenitis

Ryan K Thorpe; Megan J Foggia; Kathryn S Marcus; Bruno Policeni; Joan E Maley; Henry T Hoffman

doi:10.1002/lary.29279

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Sialographic Analysis of Radioiodine-Associated Chronic Sialadenitis

Journal article

Open access

Peer reviewed

Sialographic Analysis of Radioiodine-Associated Chronic Sialadenitis

Ryan K Thorpe, Megan J Foggia, Kathryn S Marcus, Bruno Policeni, Joan E Maley and Henry T Hoffman

The Laryngoscope, Vol.131(5), pp.E1450-E1456

05/2021

DOI: 10.1002/lary.29279

PMCID: PMC10049839

PMID: 33200832

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10049839/pdf/nihms-1881683.pdfView

Open Access

Abstract

To apply a novel sialography classification system to identify parotid and submandibular ductal findings following I-131 therapy and to assess correlates to dose and duration of symptoms. Retrospective single-center case series. Patients who underwent sialography between February 2008 and February 2019 after previously receiving I-131 treatment were identified via a retrospective chart review. Their sialograms were systematically evaluated and scored by applying the Iowa parotid sialogram scale to also include submandibular gland analysis. From 337 sialograms, 30 (five submandibular, 25 parotid) underwent analysis. Ductal stenosis was identified in all sialograms and was graded as moderate (>50%-75%) in 7/30 cases and severe (>75%) in 15/30 cases. The distal (main) duct was narrowed in 23/30 cases. No association was identified between degree of ductal stenosis and I-131 dose (P = .39), age (P = .81), or time from I-131 therapy to sialogram (P = .97). The Iowa parotid sialogram scale was successfully applied to report abnormalities of the parotid and submandibular ductal system. The most common manifestation of I-131-associated sialadenitis was a severe stenosis within the distal salivary duct. No statistically significant association was found between degree of ductal stenosis and dose of I-131, age, or duration of symptoms. 4 Laryngoscope, 131:E1450-E1456, 2021.

Adult

Aged

Dose-Response Relationship, Radiation

Female

Humans

Iodine Radioisotopes - administration & dosage

Iodine Radioisotopes - adverse effects

Male

Middle Aged

Parotid Diseases - diagnosis

Parotid Diseases - etiology

Parotid Gland - diagnostic imaging

Parotid Gland - radiation effects

Radiation Injuries - diagnosis

Radiation Injuries - etiology

Radiotherapy Dosage

Retrospective Studies

Salivary Ducts - diagnostic imaging

Salivary Ducts - radiation effects

Sialadenitis - diagnosis

Sialadenitis - etiology

Sialography - statistics & numerical data

Submandibular Gland - diagnostic imaging

Submandibular Gland - radiation effects

Submandibular Gland Diseases - diagnosis

Submandibular Gland Diseases - etiology

Thyroid Diseases - radiotherapy

Young Adult

Details

Title: Subtitle: Sialographic Analysis of Radioiodine-Associated Chronic Sialadenitis
Creators: Ryan K Thorpe - University of Iowa Hospitals and Clinics
Megan J Foggia - University of Iowa Hospitals and Clinics
Kathryn S Marcus - University of Iowa
Bruno Policeni - University of Iowa
Joan E Maley - University of Iowa
Henry T Hoffman - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: The Laryngoscope, Vol.131(5), pp.E1450-E1456
DOI: 10.1002/lary.29279
PMID: 33200832
PMCID: PMC10049839
NLM abbreviation: Laryngoscope
ISSN: 0023-852X
eISSN: 1531-4995
Grant note: T32 DC000040 / NIDCD NIH HHS
Language: English
Date published: 05/2021
Academic Unit: Radiology; Oral Pathology, Radiology and Medicine; Radiation Oncology; Otolaryngology
Record Identifier: 9984311445602771

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3 Times Cited - Web of Science