Journal article
Sidekicks: Synaptic Adhesion Molecules that Promote Lamina-Specific Connectivity in the Retina
Cell (Cambridge), Vol.110(5), pp.649-660
2002
DOI: 10.1016/S0092-8674(02)00910-8
PMID: 12230981
Abstract
A major determinant of specific connectivity in the central nervous system is that synapses made by distinct afferent populations are restricted to particular laminae in their target area. We identify Sidekick (Sdk)-1 and -2, homologous transmembrane immunoglobulin superfamily molecules that mediate homophilic adhesion in vitro and direct laminar targeting of neurites in vivo.
sdk-1 and
-2 are expressed by nonoverlapping subsets of retinal neurons; each
sdk is expressed by presynaptic (amacrine and bipolar) and postsynaptic (ganglion) cells that project to common inner plexiform (synaptic) sublaminae. Sdk proteins are concentrated at synaptic sites, and Sdk-positive synapses are restricted to the 2 (of ≥10) sublaminae to which
sdk-expressing cells project. Ectopic expression of Sdk in Sdk-negative cells redirects their processes to a Sdk-positive sublamina. These results implicate Sdks as determinants of lamina-specific synaptic connectivity.
Details
- Title: Subtitle
- Sidekicks: Synaptic Adhesion Molecules that Promote Lamina-Specific Connectivity in the Retina
- Creators
- Masahito YamagataJoshua A WeinerJoshua R Sanes
- Resource Type
- Journal article
- Publication Details
- Cell (Cambridge), Vol.110(5), pp.649-660
- DOI
- 10.1016/S0092-8674(02)00910-8
- PMID
- 12230981
- NLM abbreviation
- Cell
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2002
- Academic Unit
- Liberal Arts and Science Admin; Psychiatry; Iowa Neuroscience Institute; Biology
- Record Identifier
- 9983997437902771
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