Journal article
Signal-to-Noise Ratio for Hyperpolarized He-3 MR Imaging of Human Lungs: A 1.5 T and 3 T Comparison
Magnetic resonance in medicine, Vol.66(5), pp.1400-1404
11/01/2011
DOI: 10.1002/mrm.22920
PMID: 21523821
Abstract
The signal-to-noise ratio in hyperpolarized noble gas MR imaging is expected to be independent of field strength at frequencies typical of clinical systems (e. g., 1.5 T), where body noise dominates over coil noise. Furthermore, at higher fields (e. g., 3 T), the SNR of lung images may decline due to decreases in T-2* originating from increases in susceptibility-induced field gradients at the air-tissue interface. In this work, the SNR of hyperpolarized He-3 lung imaging at two commonly used clinical field strengths (1.5 T and 3 T) were compared in the same volunteers. Thermally polarized and hyperpolarized He-3 phantoms were used to account for differences in MR imaging system and He-3 polarizer performance, respectively, at the two field strengths. After correcting for T-2* values measured at 1.5 T (16 +/- 2 ms) and 3 T (7 +/- 1 ms), no significant difference in image SNR between the two field strengths was observed, consistent with theory. Magn Reson Med 66: 1400-1404, 2011. (C) 2011 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Signal-to-Noise Ratio for Hyperpolarized He-3 MR Imaging of Human Lungs: A 1.5 T and 3 T Comparison
- Creators
- William Dominguez-Viqueira - Sunnybrook Health Science CentreAlexei Ouriadov - Robarts Research InstituteRafael O'Halloran - Stanford UniversitySean B. Fain - University of Wisconsin–MadisonGiles E. Santyr - Robarts Research Institute
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.66(5), pp.1400-1404
- Publisher
- Wiley
- DOI
- 10.1002/mrm.22920
- PMID
- 21523821
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 5
- Grant note
- Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada (NSERC); CGIAR
- Language
- English
- Date published
- 11/01/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274957402771
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