Journal article
Signal transduction pathways in constriction of the basilar artery in vivo
Hypertension (Dallas, Tex. 1979), Vol.19(6 Pt 2), pp.739-742
06/1992
DOI: 10.1161/01.HYP.19.6.739
PMID: 1592475
Abstract
We examined effects of a putative myosin light chain kinase inhibitor in the cerebral circulation in vivo. In anesthetized rats, diameter of basilar arteries was measured through a cranial window (control, 232 +/- 10 microns, mean +/- SEM). Vessel diameter was measured during topical application of agonists and antagonists. ML-7, which has been reported to compete with adenosine triphosphate for binding to the catalytic site on myosin light chain kinase, attenuated vasoconstriction in response to prostaglandin F2 alpha (10(-6) M; -22 +/- 1% before versus -14 +/- 1% and -3 +/- 2% during ML-7, 10(-7) and 10(-6) M, respectively; p less than 0.05). ML-7 (10(-6) M) did not affect baseline diameter. Responses to serotonin (10(-8) M) and phorbol 12,13-dibutyrate (10(-8) M) were not attenuated by ML-7. Thus, constriction of the basilar artery induced by prostaglandin F2 alpha in vivo is attenuated by an inhibitor of myosin light chain kinase.
Details
- Title: Subtitle
- Signal transduction pathways in constriction of the basilar artery in vivo
- Creators
- M A Murray - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242F M FaraciD D Heistad
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.19(6 Pt 2), pp.739-742
- DOI
- 10.1161/01.HYP.19.6.739
- PMID
- 1592475
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- United States
- Grant note
- HL-16066 / NHLBI NIH HHS NS-24621 / NINDS NIH HHS HL-14388 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/1992
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040482602771
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