Journal article
Signaling Components of Redox Active Endosomes: The Redoxosomes
Antioxidants & redox signaling, Vol.11(6), pp.1313-1333
06/2009
DOI: 10.1089/ars.2008.2363
PMCID: PMC2842130
PMID: 19072143
Abstract
Subcellular compartmentalization of reactive oxygen species (ROS) plays a critical role in transmitting cell signals in response to environmental stimuli. In this regard, signals at the plasma membrane have been shown to trigger NADPH oxidase-dependent ROS production within the endosomal compartment and this step can be required for redox-dependent signal transduction. Unique features of redox-active signaling endosomes can include NADPH oxidase complex components (Nox1, Noxo1, Noxa1, Nox2, p47phox, p67phox, and/or Rac1), ROS processing enzymes (SOD1 and/or peroxiredoxins), chloride channels capable of mediating superoxide transport and/or membrane gradients required for Nox activity, and novel redox-dependent sensors that control Nox activity. This review will discuss the cytokine and growth factor receptors that likely mediate signaling through redox-active endosomes, and the common mechanisms whereby they act. Additionally, the review will cover ligand-independent environmental injuries, such as hypoxia/reoxygenation injury, that also appear to facilitate cell signaling through NADPH oxidase at the level of the endosome. We suggest that redox-active endosomes encompass a subset of signaling endosomes that we have termed
redoxosomes
. Redoxosomes are uniquely equipped with redox-processing proteins capable of transmitting ROS signals from the endosome interior to redox-sensitive effectors on the endosomal surface. In this manner, redoxosomes can control redox-dependent effector functions through the spatial and temporal regulation of ROS as second messengers.
Antioxid. Redox Signal.
11, 1313–1333.
Details
- Title: Subtitle
- Signaling Components of Redox Active Endosomes: The Redoxosomes
- Creators
- Fredrick D Oakley - Department of Anatomy and Cell BiologyDuane Abbott - Department of Anatomy and Cell BiologyQiang Li - Department of Anatomy and Cell BiologyJohn F Engelhardt - Department of Anatomy and Cell Biology
- Resource Type
- Journal article
- Publication Details
- Antioxidants & redox signaling, Vol.11(6), pp.1313-1333
- DOI
- 10.1089/ars.2008.2363
- PMID
- 19072143
- PMCID
- PMC2842130
- NLM abbreviation
- Antioxid Redox Signal
- ISSN
- 1523-0864
- eISSN
- 1557-7716
- Publisher
- Mary Ann Liebert, Inc
- Language
- English
- Date published
- 06/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984025449302771
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