Journal article
Signaling pathways critical for allergic airway inflammation
Current opinion in allergy and clinical immunology, Vol.10(1), pp.42-47
02/01/2010
DOI: 10.1097/ACI.0b013e328334f642
PMCID: PMC2838378
PMID: 19996739
Abstract
Purpose of review
Activated mast cells, basophils, and CD4(+) helper T cells have critical roles in allergic inflammation. Therefore, devising ways to specifically inhibit these cells will likely be useful for controlling allergic inflammation. We summarize recent findings regarding the role of mast cells and basophils in allergic responses and the regulation of signaling pathways downstream of the IgE receptor, the chief inducer of mast cell and basophil activation. We also highlight studies addressing the roles of the protein tyrosine kinases Zap-70 and Itk in immune system development and in the regulation of CD4(+) helper T cell responses.
Recent findings
Recent work has demonstrated that mast cell function is unexpectedly diverse and that basophils have a more prominent role in Th2-type immune responses than previously appreciated. Biochemical analysis of the IgE receptor signaling pathway has led to insights regarding the roles of phosphatases and other enzymes in this process. Studies of Zap-70 and Itk have helped to define the potential outcomes and complications of inhibiting these enzymes in order to suppress allergic inflammation.
Summary
Analysis of genetically engineered mice and biochemical studies continue to help unravel the molecular pathways that drive allergic inflammatory reactions. The knowledge acquired may lead to novel approaches for suppressing allergic inflammation.
Details
- Title: Subtitle
- Signaling pathways critical for allergic airway inflammation
- Creators
- John D. Colgan - University of IowaIsaiah L. Hankel - Univ Iowa, Dept Internal Med, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Current opinion in allergy and clinical immunology, Vol.10(1), pp.42-47
- DOI
- 10.1097/ACI.0b013e328334f642
- PMID
- 19996739
- PMCID
- PMC2838378
- NLM abbreviation
- Curr Opin Allergy Clin Immunol
- ISSN
- 1528-4050
- eISSN
- 1473-6322
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- R01AI067489 / NIH/NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01AI067489 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Anatomy and Cell Biology; Immunology; Internal Medicine
- Record Identifier
- 9984284456802771
Metrics
23 Record Views