Journal article
Signaling through the hematopoietic cytokine receptors
Annual review of immunology, Vol.13(1), pp.369-398
1995
DOI: 10.1146/annurev.iy.13.040195.002101
PMID: 7612228
Abstract
Hematopoiesis is regulated through the interaction of a variety of growth factors with specific receptors of the cytokine receptor superfamily. Although lacking catalytic domains, all the receptors couple ligand binding to the rapid induction of protein tyrosine phosphorylation. This is mediated through a novel family of protein tyrosine kinases termed the Janus kinases (Jaks) which associate with the receptors and are activated following ligand binding. Depending upon the cytokine/receptor system, one or more of the four known Jaks (Jak1, Jak2, Jak3, Tyk2) is/are involved. The activated Jaks phosphorylate both themselves and the receptor subunits, creating docking sites for SH2-containing proteins including SHC, which couples receptor engagement to activation of the ras pathway, and HCP, a protein tyrosine phosphatase which negatively affects the response. In addition, the Jaks phosphorylate one or more of a family of signal transducers and activators of transcription (Stats). Phosphorylation of Stats induces their nuclear translocation and DNA-binding activity. Activation of Stats is independent of activation of the ras pathway and represents a novel signaling pathway correlated with mitogenesis.
Details
- Title: Subtitle
- Signaling through the hematopoietic cytokine receptors
- Creators
- James N Ihle - Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USABruce A WitthuhnF W QuelleKoh YamamotoOlli Silvennoinen
- Resource Type
- Journal article
- Publication Details
- Annual review of immunology, Vol.13(1), pp.369-398
- Publisher
- United States
- DOI
- 10.1146/annurev.iy.13.040195.002101
- PMID
- 7612228
- ISSN
- 0732-0582
- eISSN
- 1545-3278
- Grant note
- P30 CA21765 / NCI NIH HHS R01 DK42932 / NIDDK NIH HHS
- Language
- English
- Date published
- 1995
- Academic Unit
- Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040554302771
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