Journal article
Signaling via Amyloid Precursor-Like Proteins APLP1 and APLP2
Journal of Alzheimer's disease, Vol.23(4), pp.689-699
03/21/2011
DOI: 10.3233/JAD-2010-101470
PMID: 21178287
Abstract
The amyloid-β protein precursor (AβPP) has been implicated in Alzheimer's disease (AD) not only as a precursor of the amyloid-β peptide but also as a mediator of signal transduction. We recently identified novel mediators of AβPP signaling via interactions with Mint/X11 family proteins Mint1 and Mint3. These mediators include transcriptional co-activators Taz and Yap. Here we show that Taz and Yap also mediate signaling via the AβPP paralogues APLP1 and APLP2 through interactions with Mint1 and Mint3. APLP1 and APLP2 formed transcriptionally active triple protein complexes with the adaptor protein Mint3 and each of the transcriptional regulators Taz and Yap, and complex formation was regulated by the γ-secretase cleavage of APLP1 and APLP2. The presence of Mint1 instead of Mint3 in the complex prevented its translocation to the nucleus. APLP1 displayed much lower transactivation levels compared to AβPP and APLP2. These results indicate that all three AβPP family members are capable of activating gene transcription via Mint3-Taz and Mint3-Yap.
Details
- Title: Subtitle
- Signaling via Amyloid Precursor-Like Proteins APLP1 and APLP2
- Creators
- Mark E Orcholski - Buck Institute for Age Research, Novato, CA, USA, Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USAQiang Zhang - Buck Institute for Age Research, Novato, CA, USADale E Bredesen - Buck Institute for Age Research, Novato, CA, USA, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of Alzheimer's disease, Vol.23(4), pp.689-699
- DOI
- 10.3233/JAD-2010-101470
- PMID
- 21178287
- ISSN
- 1387-2877
- eISSN
- 1875-8908
- Language
- English
- Date published
- 03/21/2011
- Academic Unit
- Neurology
- Record Identifier
- 9984020608702771
Metrics
9 Record Views