Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States

Connor J. Kinslow; Michael S. May; Margaret Kozak; Erqi L. Pollom; Daniel T. Chang

doi:10.1016/j.hpb.2020.03.024

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Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States

Journal article

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Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States

Connor J. Kinslow, Michael S. May, Margaret Kozak, Erqi L. Pollom and Daniel T. Chang

HPB (Oxford, England), Vol.22(12), pp.1759-1765

12/01/2020

DOI: 10.1016/j.hpb.2020.03.024

PMID: 32317226

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Abstract

Background: Signet ring cell carcinoma (SRCC) of the ampulla of Vater is poorly understood, with approximately 22 reported cases. Our study sought to create a comprehensive review of cases in the United States. Methods: We used the Surveillance, Epidemiology, and End Results Program to collect all cases of ampullary adenocarcinoma diagnosed between 2010 and 2015. Results: The age-adjusted incidence rate of SRCC of the ampulla of Vater was 1.2 cases per 10,000,000 persons per year, with 50% more cases in males than females. We identified 3448 cases of adenocarcinoma of the ampulla of Vater, 81 of which were SRCC (2.3%). SRCC tended to present a later stage than other ampullary cancers, with median survival times of 17 vs. 25 months, (p = 0.07). Survival was significantly worse for SRCC when accounting for other clinical features (HR 1.46, p = 0.01). Factors portending worse prognosis in SRCC of the ampulla of Vater were advanced age, late stage and lack of surgical intervention. Conclusion: Our study represents the largest study of SRCC of the ampulla of Vater to date. SRCC has a poorer prognosis compared with other ampullary cancers. Optimal treatment regimen is the most important future area of study.

Gastroenterology & Hepatology

Life Sciences & Biomedicine

Science & Technology

Surgery

Details

Title: Subtitle: Signet ring cell carcinoma of the Ampulla of Vater: outcomes of patients in the United States
Creators: Connor J. Kinslow - Columbia University
Michael S. May - Columbia University
Margaret Kozak - Stanford University
Erqi L. Pollom - Stanford University
Daniel T. Chang - Stanford University
Resource Type: Journal article
Publication Details: HPB (Oxford, England), Vol.22(12), pp.1759-1765
Publisher: Elsevier
DOI: 10.1016/j.hpb.2020.03.024
PMID: 32317226
ISSN: 1365-182X
eISSN: 1477-2574
Number of pages: 7
Language: English
Date published: 12/01/2020
Academic Unit: Radiation Oncology
Record Identifier: 9984312983702771

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