Journal article
Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors
Journal of neurogenetics, Vol.34(1), pp.55-68
01/02/2020
DOI: 10.1080/01677063.2019.1710144
PMCID: PMC7717672
PMID: 31955616
Abstract
Organisms respond to various environmental stressors by modulating physiology and behavior to maintain homeostasis. Steroids and catecholamines are involved in the highly conserved signaling pathways crucial for mounting molecular and cellular events that ensure immediate or long-term survival under stress conditions. The insect dopamine/ecdysteroid receptor (DopEcR) is a dual G-protein coupled receptor for the catecholamine dopamine and the steroid hormone ecdysone. DopEcR acts in a ligand-dependent manner, mediating dopaminergic signaling and unconventional "nongenomic" ecdysteroid actions through various intracellular signaling pathways. This unique feature of DopEcR raises the interesting possibility that DopEcR may serve as an integrative hub for complex molecular cascades activated under stress conditions. Here, we review previously published studies of Drosophila DopEcR in the context of stress response and also present newly discovered DopEcR loss-of-function phenotypes under different stress conditions. These findings provide corroborating evidence that DopEcR plays vital roles in responses to various stressors, including heat, starvation, alcohol, courtship rejection, and repeated neuronal stimulation in Drosophila. We further discuss what is known about DopEcR in other insects and DopEcR orthologs in mammals, implicating their roles in stress responses. Overall, this review highlights the importance of dual GPCRs for catecholamines and steroids in modulating physiology and behavior under stress conditions. Further multidisciplinary studies of Drosophila DopEcR will contribute to our basic understanding of the functional roles and underlying mechanisms of this class of GPCRs.
Details
- Title: Subtitle
- Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors
- Creators
- Emily Petruccelli - Department of Biological Sciences, Southern Illinois University EdwardsvilleArianna Lark - Department of Pharmacology and Toxicology, Virginia Commonwealth UniversityJames A Mrkvicka - Interdisciplinary Graduate Program in Genetics, University of IowaToshihiro Kitamoto - Department of Anesthesia, Carver College of Medicine, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neurogenetics, Vol.34(1), pp.55-68
- DOI
- 10.1080/01677063.2019.1710144
- PMID
- 31955616
- PMCID
- PMC7717672
- NLM abbreviation
- J Neurogenet
- ISSN
- 0167-7063
- eISSN
- 1563-5260
- Publisher
- Taylor & Francis
- Grant note
- F31AA021625 / NIH R03AA021968 / NIH T32GM008629 / NIH University of Iowa Graduate College Dean's Graduate Fellowship (AL) R01MH085081 / NIH Chateaubriand Fellowship T32NS007421 / NIH IOS1352882 / NSF T32NS045549 / NIH
- Language
- English
- Date published
- 01/02/2020
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984070309002771
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