Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study

Sirous Darabian; Jye-Yu C Backlund; Patricia A Cleary; Nasim Sheidaee; Ionut Bebu; John M Lachin; Matthew J Budoff; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group

doi:10.1371/journal.pone.0159958

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Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study

Journal article

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Peer reviewed

Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study

Sirous Darabian, Jye-Yu C Backlund, Patricia A Cleary, Nasim Sheidaee, Ionut Bebu, John M Lachin, Matthew J Budoff and Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group

PloS one, Vol.11(7), pp.e0159958-e0159958

2016

DOI: 10.1371/journal.pone.0159958

PMCID: PMC4961378

PMID: 27459689

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Abstract

Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels' density of -30 to -190 Hounsfield Unit. The associations were assessed using-Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. The weighted mean age was 43 years (range 32-57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p<0.001). After adjusting for gender and age, participants with greater BMI, higher waist to hip ratio (WTH), higher weighted HbA1c, elevated triglyceride level, and a history of albumin excretion rate of equal or greater than 300 mg/d (AER≥300) or end stage renal disease (ESRD) had significantly larger EAT/IAT volumes. T1DM patients with greater BMI, WTH ratio, weighted HbA1c level, triglyceride level and AER≥300/ESRD had significantly larger EAT/IAT volumes. Larger sample size studies are recommended to evaluate independency.

Adipose Tissue - diagnostic imaging

Adult

Diabetes Mellitus, Type 1 - blood

Diabetes Mellitus, Type 1 - complications

Diabetes Mellitus, Type 1 - diagnostic imaging

Diabetic Cardiomyopathies - epidemiology

Female

Hemoglobin A - metabolism

Humans

Male

Middle Aged

Pericardium - diagnostic imaging

Pilot Projects

Thoracic Cavity - diagnostic imaging

Triglycerides - blood

Details

Title: Subtitle: Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study
Creators: Sirous Darabian - Los Angeles Biomedical Research institute, Torrance, California, United States of America
Jye-Yu C Backlund - The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America
Patricia A Cleary - The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America
Nasim Sheidaee - Los Angeles Biomedical Research institute, Torrance, California, United States of America
Ionut Bebu - The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America
John M Lachin - The Biostatistics Center, the George Washington University, Rockville, Maryland, United States of America
Matthew J Budoff - Los Angeles Biomedical Research institute, Torrance, California, United States of America
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group
Contributors: L Snetselaar (Contributor) - University of Iowa, Fraternal Order of Eagles Diabetes Research Center
Resource Type: Journal article
Publication Details: PloS one, Vol.11(7), pp.e0159958-e0159958
DOI: 10.1371/journal.pone.0159958
PMID: 27459689
PMCID: PMC4961378
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Grant note: U01 DK094157 / NIDDK NIH HHS U01 DK094176 / NIDDK NIH HHS
Language: English
Date published: 2016
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984215050502771

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