Journal article
Significance of Hyperferritinemia in Hospitalized Adults
The American journal of the medical sciences, Vol.354(2), pp.152-158
08/2017
DOI: 10.1016/j.amjms.2017.04.016
PMID: 28864373
Abstract
Although high ferritin levels are associated with iron overload, it is known that ferritin is also an acute-phase reactant that may be elevated in conditions associated with acute and chronic inflammation. In addition, an elevated ferritin level is a criterion for the diagnosis of hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Therefore, the significance of elevated serum ferritin is often unclear. As HLH/MAS is a medical emergency, prompt diagnosis is important to guide appropriate treatment.
To study the spectrum of diagnoses associated with elevated serum ferritin, we did a retrospective review of adult patients admitted to our academic medical center from 2008-2012 with serum ferritin levels greater than 2,000ng/mL. The degree of hyperferritinemia was compared to different diagnoses and selected laboratory values.
A total of 333 patients were identified with a serum ferritin level >2,000ng/mL. Hepatocellular injury was the most prevalent diagnosis with n = 126; infection was next with n = 96. Eleven patients were diagnosed with HLH/MAS.
Elevated ferritin, as an isolated finding, was not a specific marker for the diagnosis of HLH/MAS. However, as a group, HLH/MAS patients had the highest mean and median ferritin values.
Details
- Title: Subtitle
- Significance of Hyperferritinemia in Hospitalized Adults
- Creators
- Meredith Schaffner - University of Iowa Hospitals and ClinicsLori Rosenstein - Gundersen Health SystemZuhair Ballas - University of Iowa Hospitals and ClinicsManish Suneja - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.354(2), pp.152-158
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.amjms.2017.04.016
- PMID
- 28864373
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Language
- English
- Date published
- 08/2017
- Academic Unit
- Nephrology; Immunology; Internal Medicine
- Record Identifier
- 9984359925102771
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