Journal article
Significance of PIVKA-II in sorafenib therapy for advanced hepatocellular carcinoma
Kanzo, Vol.51(7), pp.403-404
2010
DOI: 10.2957/kanzo.51.403
Abstract
We investigated changes in tumor markers before and after sorafenib therapy for advanced hepatocellular carcinoma (HCC). Subjects were 28 patients who began sorafenib therapy. HCC stage was III (n = 5), IVA (n = 10) and IVB (n = 13). AFP, AFP-L3 and PIVKA-II were compared before and at one month after sorafenib administration. While no significant changes were observed for AFP and AFP-L3, PIVKA-II increased significantly following treatment (p<0.001). Similar results were observed for investigation of outcomes based on RECIST criteria (PR, n = 1; SD, n = 18; PD, n = 9), with increases also observed for PR or SD patients. PIVKA-II increased following sorafenib administration regardless of therapeutic effects based on imaging findings. The present results are very interesting from the perspective of the clinical effects of sorafenib. © 2010 The Japan Society of Hepatology.
Details
- Title: Subtitle
- Significance of PIVKA-II in sorafenib therapy for advanced hepatocellular carcinoma
- Creators
- Teiji Kuzuya - Musashino Red Cross HospitalKaoru Tsuchiya - Musashino Red Cross HospitalKeisuke Tanaka - Musashino Red Cross HospitalYuichiro Suzuki - Musashino Red Cross HospitalTakahide Hoshioka - Musashino Red Cross HospitalShinji Tamaki - Musashino Red Cross HospitalTomoji Kato - Musashino Red Cross HospitalYutaka Yasui - Musashino Red Cross HospitalTomohiro Tanaka - Musashino Red Cross HospitalTakanori Hosokawa - Musashino Red Cross HospitalKen Ueda - Musashino Red Cross HospitalHiroyuki Nakanishi - Musashino Red Cross HospitalJun Itakura - Musashino Red Cross HospitalMasayuki Kurosaki - Musashino Red Cross HospitalYasuhiro Asahina - Musashino Red Cross HospitalNamiki Izumi - Musashino Red Cross Hospital
- Resource Type
- Journal article
- Publication Details
- Kanzo, Vol.51(7), pp.403-404
- DOI
- 10.2957/kanzo.51.403
- ISSN
- 0451-4203
- eISSN
- 1881-3593
- Language
- Japanese
- Date published
- 2010
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984359933502771
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