Journal article
Significance of autoantibody seropositivity in children with obesity and non-alcoholic fatty liver disease
Pediatric obesity, Vol.16(1), pp.e12696-n/a
01/2021
DOI: 10.1111/ijpo.12696
PMID: 32638543
Abstract
Background Autoantibodies are frequently positive in adults with nonalcoholic fatty liver disease (NAFLD) without concurrent autoimmune hepatitis (AIH). The clinical significance of this is unknown in children. Objective To determine the prevalence of autoantibody positivity in pediatric NAFLD and to evaluate its association with disease severity. Methods Multicenter, retrospective study of patients <= 18 years of age with biopsy-confirmed NAFLD. Descriptive statistics were used and groups were compared using Wilcoxon-Mann Whitney or chi(2)testing, and multivariable logistic regression was used for binary or ordinal outcomes. Results One hundred and thirty six patients with a median age of 14 years were included. The median body mass indexZ-score was 2.5 (interquartile range 2.2, 2.6). Positive antinuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-liver-kidney microsomal antibody, or any combination of autoantibodies were observed in 22%, 14%, 0%, and 33% of patients, respectively. The proportion of patients with a steatosis score >= 2 was significantly higher in those with positive ANA (P= .045). In the multivariable regression analysis, positive ANA was associated with increased odds of steatosis score >= 2 (odds ratio, 5.91; 95% confidential interval, 1.50-23.26), after controlling for potential confounders. No other significant histology differences were seen between the groups. Conclusions Positive ANA and ASMA are common in children with NAFLD; however, anti-LKM positivity is not. ANA positivity is associated with more severe steatosis.
Details
- Title: Subtitle
- Significance of autoantibody seropositivity in children with obesity and non-alcoholic fatty liver disease
- Creators
- Toshifumi Yodoshi - Cincinnati Children's Hospital Medical CenterSarah Orkin - Cincinnati Children's Hospital Medical CenterAna Catalina Arce-Clachar - Cincinnati Children's Hospital Medical CenterKristin Bramlage - Cincinnati Children's Hospital Medical CenterStavra A. Xanthakos - Cincinnati Children's Hospital Medical CenterMarialena Mouzaki - Cincinnati Children's Hospital Medical CenterPamela L. Valentino - Yale University
- Resource Type
- Journal article
- Publication Details
- Pediatric obesity, Vol.16(1), pp.e12696-n/a
- DOI
- 10.1111/ijpo.12696
- PMID
- 32638543
- NLM abbreviation
- Pediatr Obes
- ISSN
- 2047-6302
- eISSN
- 2047-6310
- Publisher
- Wiley
- Number of pages
- 8
- Language
- English
- Date published
- 01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9985214173302771
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