Journal article
Significance of preformed anti-donor antibodies in liver transplantation
Transplantation, Vol.63(1), pp.84-88
01/01/1997
DOI: 10.1097/00007890-199701150-00016
PMID: 9000666
Abstract
The significance of a positive cross-match in liver transplantation remains controversial, as documented by a number of recent conflicting reports. In this study, we evaluated 195 consecutive orthotopic liver transplant recipients in whom the cross-match was either negative or positive for T or B cells. Special emphasis was placed on the outcome of patients with high levels of preformed IgG antibodies directed against donor T cells. IgG anti-donor antibodies were confirmed by flow cytometry in all cases. Of 10 patients with strong T-cell antibodies, there was one early death due to nonimmunological causes. Transplantation was successful in 9 /10 patients followed for 3 months to 3 years. Graft survival, incidence of acute rejection, and number of liver biopsies in patients with a positive cross-match (strong T, weak T, or B cell) were not significantly different from those of patients with a negative cross-match. In the strong T cell antibody group, one patient had early graft dysfunction, with extensive hepatic necrosis and histological signs of antibody-induced damage. Two other patients also showed some evidence of possible antibody-mediated events, such as neutrophil infiltration and hepatocyte swelling. These lesions were reversible, and the patients had uneventful recoveries. Thus, in our experience, preformed antibodies did not preclude good graft survival.
Details
- Title: Subtitle
- Significance of preformed anti-donor antibodies in liver transplantation
- Creators
- S Fujita - Department of Pathology, University of Florida College of Medicine, Gainesville 32610, USA.C RosenA Reed - University of Florida Health Science CenterMax R Langham Jr - University of FloridaR Howard - University of Florida HealthG Lauwers - University of Florida Health Science CenterJ Scornik - University of Florida Health Science Center
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.63(1), pp.84-88
- DOI
- 10.1097/00007890-199701150-00016
- PMID
- 9000666
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Language
- English
- Date published
- 01/01/1997
- Academic Unit
- Accounting; Surgery
- Record Identifier
- 9984322804502771
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