Significant CD5 expression on normal stage 3 hematogones and mature B Lymphocytes in bone marrow

Franklin S Fuda; Nitin J Karandikar; Weina Chen

doi:10.1309/AJCPU5E3NXEKLFIY

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Significant CD5 expression on normal stage 3 hematogones and mature B Lymphocytes in bone marrow

Journal article

Open access

Peer reviewed

Significant CD5 expression on normal stage 3 hematogones and mature B Lymphocytes in bone marrow

Franklin S Fuda, Nitin J Karandikar and Weina Chen

American journal of clinical pathology, Vol.132(5), pp.733-737

11/2009

DOI: 10.1309/AJCPU5E3NXEKLFIY

PMID: 19846815

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Abstract

B-cell maturation from hematogones to mature B cells in bone marrow exhibits a consistent, complex spectrum of sequential antigen expression. CD5 expression, however, has not been characterized. We studied the dynamics of CD5 expression on developing B cells by 4-color flow cytometry in 32 patients, aged 9 months to 63 years, with hematogone hyperplasia (>3.5% of total events). The mean percentage of hematogones was 8.1%. We demonstrate consistent CD5 expression on normal, polytypic B cells in a continuum, predominantly at later stages of maturation, specifically on stage 3 hematogones and mature B cells. Awareness of this normal pattern of CD5 expression on B-cell subsets has implications in the analysis of minimal residual disease of CD5+ B-lineage non-Hodgkin lymphomas.

Neoplasm, Residual - pathology

B-Lymphocytes - cytology

Gene Expression

Neoplasm, Residual - metabolism

Humans

Middle Aged

B-Lymphocyte Subsets - cytology

CD5 Antigens - biosynthesis

Infant

Male

Gene Expression Profiling

Hematopoietic Stem Cells - metabolism

Lymphoma, Non-Hodgkin - pathology

Flow Cytometry

B-Lymphocyte Subsets - metabolism

Hematopoietic Stem Cells - cytology

Lymphoma, Non-Hodgkin - metabolism

Adult

Female

Cell Differentiation - physiology

B-Lymphocytes - metabolism

Bone Marrow Cells - metabolism

Details

Title: Subtitle: Significant CD5 expression on normal stage 3 hematogones and mature B Lymphocytes in bone marrow
Creators: Franklin S Fuda - Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA
Nitin J Karandikar
Weina Chen
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.132(5), pp.733-737
Publisher: England
DOI: 10.1309/AJCPU5E3NXEKLFIY
PMID: 19846815
ISSN: 0002-9173
eISSN: 1943-7722
Language: English
Date published: 11/2009
Academic Unit: Pathology
Record Identifier: 9984047865002771

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