Silent cerebral infarction in patients enrolled in the TOAST study

P. H DAVIS; W. R CLARKE; B. H BENDIXEN; H. P ADAMS; R. F WOOLSON; A CULEBRAS

doi:10.1212/WNL.46.4.942

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Silent cerebral infarction in patients enrolled in the TOAST study

Journal article

Peer reviewed

Silent cerebral infarction in patients enrolled in the TOAST study

P. H DAVIS, W. R CLARKE, B. H BENDIXEN, H. P ADAMS, R. F WOOLSON and A CULEBRAS

Neurology, Vol.46(4), pp.942-948

1996

DOI: 10.1212/WNL.46.4.942

PMID: 8780069

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Abstract

To determine the frequency, location, size, and risk factors for silent cerebral infarctions (SCIs) on brain CT, we identified 629 patients without a history of previous stroke who were enrolled in a multicenter clinical trial of therapy for acute ischemic stroke. On the baseline CT, 143 patients (22.7%) had SCIs; 34.3% of the lesions were in the right hemisphere, 38.5% in the left hemisphere, and 27.3% were bilateral. The lesion size was < 1 cm in 65.7%, and the most common site was the basal ganglia (48.3%). Patients with SCI were compared with controls without SCI to determine the odds ratios (ORs) for each risk factor. On univariate analysis, race (black versus white) had an OR of 1.80 (95% confidence interval [CI], 1.14 to 2.85), male sex an OR of 1.68 (95% CI, 1.12 to 2.51), and congestive heart failure an OR of 1.88 (95% CI, 1.07 to 3.31). Significant risk factors on multivariate analysis include age (OR 1.03 per year, p = 0.0070), male sex (OR 1.78, p = 0.0094), and race (OR 2.43, p = 0.0004). After including interaction terms with age and hypertension and age, sex, and race, hypertension was also a significant risk factor.

Neurology

Biological and medical sciences

Vascular diseases and vascular malformations of the nervous system

Medical sciences

Details

Title: Subtitle: Silent cerebral infarction in patients enrolled in the TOAST study
Creators: P. H DAVIS - Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1053, United States
W. R CLARKE - Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1053, United States
B. H BENDIXEN - Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1053, United States
H. P ADAMS - Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1053, United States
R. F WOOLSON - Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1053, United States
A CULEBRAS - Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242-1053, United States
Resource Type: Journal article
Publication Details: Neurology, Vol.46(4), pp.942-948
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
DOI: 10.1212/WNL.46.4.942
PMID: 8780069
ISSN: 0028-3878
eISSN: 1526-632X
Language: English
Date published: 1996
Academic Unit: Statistics and Actuarial Science; Neurology; Epidemiology; Iowa Neuroscience Institute; Biostatistics
Record Identifier: 9984020777102771

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