Silver diamine fluoride effectiveness in arresting initial approximal caries lesions in adults: A triple-blinded, randomized controlled clinical trial

Maram Jaradat; Justine Kolker; Arwa Owais; Sandra Guzman-Armstrong; Amanda Haes; Sindhura Anamali; Carissa Comnick; Erliang Zeng; Michael Kanellis

doi:10.4103/JCDE.JCDE_83_25

Journal article

Silver diamine fluoride effectiveness in arresting initial approximal caries lesions in adults: A triple-blinded, randomized controlled clinical trial

Maram Jaradat, Justine Kolker, Arwa Owais, Sandra Guzman-Armstrong, Amanda Haes, Sindhura Anamali, Carissa Comnick, Erliang Zeng and Michael Kanellis

Journal of conservative dentistry and endodontics, Vol.28(9), pp.892-898

09/01/2025

DOI: 10.4103/JCDE.JCDE_83_25

PMCID: PMC12440336

PMID: 40964644

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Abstract

AbstractAim:Despite the advancement in dental care, dental caries remains the most prevalent oral disease, necessitating the need for effective, preventive, and minimally invasive treatment options. The aim of this study was to evaluate the effectiveness of silver diamine fluoride (SDF) in arresting initial approximal carious lesions in adults.Materials and Methods:This study was a randomized, triple-blinded, placebo-controlled clinical trial. Participants were randomly assigned to one of two arms (A or B). One randomly selected lesion received either treatment (SDF solution) or placebo (water). Lesions were followed at 6- and 12-month using bitewing radiographs. Lesion progression was assessed via three evaluation methods: (1) pairwise comparison of bitewing radiographs (visual assessment), (2) assessment of subtraction radiographs (digital subtraction radiography [DSR]), and (3) histogram analysis of subtraction radiographs (HA). All the statistical analyses were performed using R software (the R Foundation, Vienna, Austria) at the 5% significance level.Results:Over 12-month period, more than 90% of the lesions were arrested in both groups. The SDF group performed significantly better according to the DSR method between baseline and 6 months (P = 0.05). There were no significant differences between the groups at the 12-month follow-up.Conclusion:SDF treatment was superior in arresting initial approximal caries lesions during the first 6 months of use. This is significant for disease control in high-risk individuals who present to the clinic with multiple initial approximal caries lesions. Further studies are needed to confirm its effectiveness.

Clinical Trials

Dental Caries

Disease Control

Fluorides

Radiography

Fluoride treatments

Lesions

Performance evaluation

Placebos

Statistical analysis

Details

Title: Subtitle: Silver diamine fluoride effectiveness in arresting initial approximal caries lesions in adults: A triple-blinded, randomized controlled clinical trial
Creators: Maram Jaradat - University of Iowa
Justine Kolker - University of Iowa, Operative Dentistry
Arwa Owais - University of Iowa
Sandra Guzman-Armstrong - University of Iowa
Amanda Haes - University of Iowa
Sindhura Anamali - University of Iowa, Oral Pathology, Radiology and Medicine
Carissa Comnick - University of Iowa
Erliang Zeng - University of Iowa, Iowa Neuroscience Institute
Michael Kanellis - University of Iowa
Resource Type: Journal article
Publication Details: Journal of conservative dentistry and endodontics, Vol.28(9), pp.892-898
DOI: 10.4103/JCDE.JCDE_83_25
PMID: 40964644
PMCID: PMC12440336
NLM abbreviation: J Conserv Dent Endod
ISSN: 2950-4716
eISSN: 2950-4708
Publisher: Medknow Publications & Media Pvt. Ltd
Number of pages: 7
Language: English
Date published: 09/01/2025
Academic Unit: Preventive and Community Dentistry; Radiology; Oral Pathology, Radiology and Medicine; Iowa Neuroscience Institute; Biostatistics; Pediatric Dentistry; Operative Dentistry; Dental Research
Record Identifier: 9984958607302771

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