Journal article
Simulated remodeling of loaded collagen networks via strain-dependent enzymatic degradation and constant-rate fiber growth
Mechanics of materials, Vol.44, pp.72-82
2012
DOI: 10.1016/j.mechmat.2011.07.003
PMCID: PMC3237686
PMID: 22180691
Abstract
Recent work has demonstrated that enzymatic degradation of collagen fibers exhibits strain-dependent kinetics. Conceptualizing how the strain dependence affects remodeling of collagenous tissues is vital to our understanding of collagen management in native and bioengineered tissues. As a first step towards this goal, the current study puts forward a multiscale model for enzymatic degradation and remodeling of collagen networks for two sample geometries we routinely use in experiments as model tissues. The multiscale model, driven by microstructural data from an enzymatic decay experiment, includes an exponential strain-dependent kinetic relation for degradation and constant growth. For a dogbone sample under uniaxial load, the model predicted that the distribution of fiber diameters would spread over the course of degradation because of variation in individual fiber load. In a cross-shaped sample, the central region, which experiences smaller, more isotropic loads, showed more decay and less spread in fiber diameter compared to the arms. There was also a slight shift in average orientation in different regions of the cruciform.
Details
- Title: Subtitle
- Simulated remodeling of loaded collagen networks via strain-dependent enzymatic degradation and constant-rate fiber growth
- Creators
- M.F Hadi - Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church St. SE, Minneapolis, MN 55455, United StatesE.A Sander - Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church St. SE, Minneapolis, MN 55455, United StatesJ.W Ruberti - Department of Mechanical and Industrial Engineering, Northeastern University, 334 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115, United StatesV.H Barocas - Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church St. SE, Minneapolis, MN 55455, United States
- Resource Type
- Journal article
- Publication Details
- Mechanics of materials, Vol.44, pp.72-82
- DOI
- 10.1016/j.mechmat.2011.07.003
- PMID
- 22180691
- PMCID
- PMC3237686
- NLM abbreviation
- Mech Mater
- ISSN
- 0167-6636
- eISSN
- 1872-7743
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
- Record Identifier
- 9984064554902771
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