Journal article
Simultaneous MRI of Lung Structure and Perfusion in a Single Breathhold
Journal of magnetic resonance imaging, Vol.41(1), pp.52-59
01/01/2015
DOI: 10.1002/jmri.24520
PMCID: PMC4065224
PMID: 24357054
Abstract
PurposeTo develop and demonstrate a breathheld 3D radial ultrashort echo time (UTE) acquisition to visualize co-registered lung perfusion and vascular structure.
Materials and MethodsNine healthy dogs were scanned twice at 3 Tesla (T). Contrast-enhanced pulmonary perfusion scans were acquired with a temporally interleaved three-dimensional (3D) radial UTE (TE=0.08 ms) sequence in a breathhold (1 s time frames over a 33 s breathhold). The 3D breathheld volume was reconstructed into time-resolved perfusion datasets, and a composite vascular structure dataset. For structural comparison, a 5 min respiratory-gated 3D radial UTE scan was acquired. Data were analyzed by quantitative metrics and radiologist scoring.
ResultsAppropriate time-course of contrast was seen in all subjects. Right ventricle to aorta transit times were 7.42.0 s. Relative lung enhancement was a factor of 8.4 +/- 1.5. Radiologist scoring showed similarly excellent visualization of the pulmonary arteries to the subsegmental level in breathheld (94% of cases) and respiratory-gated (100% of cases) acquisitions (P=0.33) despite the aggressive under sampling in the breathheld scan. Similarly, differentiation of lung tissue and airways was achieved by both acquisition methods.
ConclusionA time-resolved 3D radial UTE sequence for simultaneous imaging of pulmonary perfusion and co-registered vascular structure is feasible. J. Magn. Reson. Imaging 2015;41:52-59. (c) 2013 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Simultaneous MRI of Lung Structure and Perfusion in a Single Breathhold
- Creators
- Laura C. Bell - University of Wisconsin–MadisonKevin M. Johnson - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–MadisonAndrew Wentland - University of Wisconsin–MadisonRandi Drees - University of Wisconsin–MadisonRebecca A. Johnson - University of Wisconsin–MadisonGrzegorz Bauman - University of Wisconsin–MadisonChristopher J. Francois - University of Wisconsin–MadisonScott K. Nagle - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.41(1), pp.52-59
- Publisher
- Wiley
- DOI
- 10.1002/jmri.24520
- PMID
- 24357054
- PMCID
- PMC4065224
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Number of pages
- 8
- Grant note
- F30 HL108539-02 / Kirschstein National Research Service Award; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 1UL1RR025011; 9U54TR000021 / Clinical and Translational Science Award (CTSA) program; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) F30HL108539 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) UL1RR025011 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) T32 GM008692 / NIH Medical Scientist Training Program; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32GM008692 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274953702771
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