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Simultaneous QSM and metabolic imaging of the brain using SPICE
Journal article   Peer reviewed

Simultaneous QSM and metabolic imaging of the brain using SPICE

Xi Peng, Fan Lam, Yudu Li, Bryan Clifford and Zhi-Pei Liang
Magnetic resonance in medicine, Vol.79(1), pp.13-21
01/2018
DOI: 10.1002/mrm.26972
PMCID: PMC5744903
PMID: 29067730
url
https://www.ncbi.nlm.nih.gov/pmc/articles/5744903View
Open Access

Abstract

To map brain metabolites and tissue magnetic susceptibility simultaneously using a single three-dimensional H-MRSI acquisition without water suppression. The proposed technique builds on a subspace imaging method called spectroscopic imaging by exploiting spatiospectral correlation (SPICE), which enables ultrashort echo time (TE)/short pulse repetition time (TR) acquisitions for H-MRSI without water suppression. This data acquisition scheme simultaneously captures both the spectral information of brain metabolites and the phase information of the water signals that is directly related to tissue magnetic susceptibility variations. In extending this scheme for simultaneous QSM and metabolic imaging, we increase k-space coverage by using dual density sparse sampling and ramp sampling to achieve spatial resolution often required by QSM, while maintaining a reasonable signal-to-noise ratio (SNR) for the spatiospectral data used for metabolite mapping. In data processing, we obtain high-quality QSM from the unsuppressed water signals by taking advantage of the larger number of echoes acquired and any available anatomical priors; metabolite spatiospectral distributions are reconstructed using a union-of-subspaces model. In vivo experimental results demonstrate that the proposed method can produce susceptibility maps at a resolution higher than 1.8 × 1.8 × 2.4 mm along with metabolite spatiospectral distributions at a nominal spatial resolution of 2.4 × 2.4 × 2.4 mm from a single 7-min MRSI scan. The estimated susceptibility values are consistent with those obtained using the conventional QSM method with 3D multi-echo gradient echo acquisitions. This article reports a new capability for simultaneous susceptibility mapping and metabolic imaging of the brain from a single H-MRSI scan, which has potential for a wide range of applications. Magn Reson Med 79:13-21, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
 Algorithms Brain - diagnostic imaging Brain Mapping - methods Healthy Volunteers Humans Image Interpretation, Computer-Assisted - methods Image Processing, Computer-Assisted Magnetic Resonance Imaging - methods Models, Statistical Reproducibility of Results Signal-To-Noise Ratio Water - metabolism

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