Simultaneous auditory agnosia: Systematic description of a new type of auditory segregation deficit following a right hemisphere lesion

Emma Holmes; Nattawan Utoomprurkporn; Chandrashekar Hoskote; Jason D. Warren; Doris-Eva Bamiou; Timothy D. Griffiths

doi:10.1016/j.cortex.2020.10.023

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Simultaneous auditory agnosia: Systematic description of a new type of auditory segregation deficit following a right hemisphere lesion

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Simultaneous auditory agnosia: Systematic description of a new type of auditory segregation deficit following a right hemisphere lesion

Emma Holmes, Nattawan Utoomprurkporn, Chandrashekar Hoskote, Jason D. Warren, Doris-Eva Bamiou and Timothy D. Griffiths

Cortex, Vol.135, pp.92-107

02/01/2021

DOI: 10.1016/j.cortex.2020.10.023

PMCID: PMC7856551

PMID: 33360763

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Abstract

We investigated auditory processing in a young patient who experienced a single embolus causing an infarct in the right middle cerebral artery territory. This led to damage to auditory cortex including planum temporale that spared medial Heschl's gyrus, and included damage to the posterior insula and inferior parietal lobule. She reported chronic difficulties with segregating speech from noise and segregating elements of music. Clinical tests showed no evidence for abnormal cochlear function. Follow-up tests confirmed difficulties with auditory segregation in her left ear that spanned multiple domains, including words-in-noise and music streaming. Testing with a stochastic figure-ground taskda way of estimating generic acoustic foreground and background segregationddemonstrated that this was also abnormal. This is the first demonstration of an acquired deficit in the segregation of complex acoustic patterns due to cortical damage, which we argue is a causal explanation for the symptomatic deficits in the segregation of speech and music. These symptoms are analogous to the visual symptom of simultaneous agnosia. Consistent with functional imaging studies on normal listeners, the work implicates non-primary auditory cortex. Further, the work demonstrates a (partial) lateralisation of the necessary anatomical substrate for segregation that has not been previously highlighted. (C) 2020 The Authors. Published by Elsevier Ltd.

Behavioral Sciences

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Psychology

Psychology, Experimental

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Social Sciences

Details

Title: Subtitle: Simultaneous auditory agnosia: Systematic description of a new type of auditory segregation deficit following a right hemisphere lesion
Creators: Emma Holmes - University College London
Nattawan Utoomprurkporn - King Chulalongkorn Memorial Hospital
Chandrashekar Hoskote - University College London
Jason D. Warren - UK Dementia Research Institute
Doris-Eva Bamiou - UCL, UCL Ear Inst, London, England
Timothy D. Griffiths - Newcastle University
Resource Type: Journal article
Publication Details: Cortex, Vol.135, pp.92-107
Publisher: Elsevier
DOI: 10.1016/j.cortex.2020.10.023
PMID: 33360763
PMCID: PMC7856551
ISSN: 0010-9452
eISSN: 1973-8102
Number of pages: 16
Grant note: WT091681MA; DC000242-31 / Alzheimer's Society NIHR UCL/UCLH Biomedical Research Centre Alzheimer's Research UK; Alzheimer's Research UK (ARUK)
Language: English
Date published: 02/01/2021
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984627325502771

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