Journal article
Simultaneous imaging of C-13 metabolism and H-1 structure: technical considerations and potential applications
NMR in biomedicine, Vol.28(5), pp.576-582
05/01/2015
DOI: 10.1002/nbm.3279
PMCID: PMC4426883
PMID: 25810146
Abstract
Real-time imaging of C-13 metabolism in vivo has been enabled by recent advances in hyperpolarization. As a result of the inherently low natural abundance of endogenous C-13 nuclei, hyperpolarized C-13 images lack structural information that could be used to aid in motion detection and anatomical registration. Motion before or during the C-13 acquisition can therefore result in artifacts and misregistration that may obscure measures of metabolism. In this work, we demonstrate a method to simultaneously image both H-1 and C-13 nuclei using a dual-nucleus spectral-spatial radiofrequency excitation and a fully coincident readout for rapid multinuclear spectroscopic imaging. With the appropriate multinuclear hardware, and the means to simultaneously excite and receive on both channels, this technique is straightforward to implement requiring little to no increase in scan time. Phantom and in vivo experiments were performed with both Cartesian and spiral trajectories to validate and illustrate the utility of simultaneous acquisitions. Motion compensation of dynamic metabolic measurements acquired during free breathing was demonstrated using motion tracking derived from H-1 data. Simultaneous multinuclear imaging provides structural H-1 and metabolic C-13 images that are correlated both spatially and temporally, and are therefore amenable to joint H-1 and C-13 analysis and correction of structure-function images. Copyright (c) 2015 John Wiley & Sons, Ltd.
Details
- Title: Subtitle
- Simultaneous imaging of C-13 metabolism and H-1 structure: technical considerations and potential applications
- Creators
- Jeremy W. Gordon - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–MadisonDavid J. Niles - University of Wisconsin–MadisonKai D. Ludwig - University of Wisconsin–MadisonKevin M. Johnson - University of Wisconsin–MadisonEric T. Peterson - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- NMR in biomedicine, Vol.28(5), pp.576-582
- DOI
- 10.1002/nbm.3279
- PMID
- 25810146
- PMCID
- PMC4426883
- NLM abbreviation
- NMR Biomed
- ISSN
- 0952-3480
- eISSN
- 1099-1492
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- P50AG033514 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) T32 CA009206 / Medical Physics NCI Radiological Sciences Training Grant NIH/NCI UL1TR000427; TL1TR000429 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30 CA014520 / Carbone Comprehensive Cancer Center (UWCCC) [NIH/National Cancer Institute (NCI)] UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) P50 AG033514 / University of Wisconsin Alzheimer's Disease Research Center [National Institutes of Health (NIH)]; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA GE Healthcare; General Electric University of Wisconsin Graduate School
- Language
- English
- Date published
- 05/01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274958702771
Metrics
8 Record Views