Journal article
Simvastatin: present and future perspectives
Expert Opinion on Pharmacotherapy, Vol.8(13), pp.2159-2127
09/01/2007
DOI: 10.1517/14656566.8.13.2159
PMID: 17714068
Abstract
Simvastatin is lipophilic statin with a short half-life that is primarily metabolized by CYP450 3A4. At doses of 5 - 80 mg, simvastatin lowers LDL cholesterol by 25 - 50%. Simvastatin has been shown to reduce the risk of cardiovascular disease by 35% and overall mortality by up to 30% over 5 years. The recommended starting dose of simvastatin 40 mg is approved as a lipid-lowering agent and for all high-risk patients, including those with cardiovascular disease and diabetes, regardless of the baseline LDL level. Simvastatin dose should be adjusted in those receiving CYP3A4 inhibitors, gemfibrozil, or ciclosporin, amiodarone, or in those with severe renal insufficiency. Coformulation of simvastatin with ezetimibe is now available, and coformulation with extended release niacin is under development.
Details
- Title: Subtitle
- Simvastatin: present and future perspectives
- Creators
- Jennifer G Robinson
- Resource Type
- Journal article
- Publication Details
- Expert Opinion on Pharmacotherapy, Vol.8(13), pp.2159-2127
- Publisher
- Taylor & Francis
- DOI
- 10.1517/14656566.8.13.2159
- PMID
- 17714068
- ISSN
- 1465-6566
- eISSN
- 1744-7666
- Language
- English
- Date published
- 09/01/2007
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983996084202771
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