Journal article
Single High-dose Vitamin D3 Supplementation in Pediatric Patients With Inflammatory Bowel Disease and Hypovitaminosis D
Journal of pediatric gastroenterology and nutrition, Vol.70(4), pp.E77-E80
04/01/2020
DOI: 10.1097/MPG.0000000000002590
PMID: 31860537
Abstract
Objectives: The primary aim was to determine the effectiveness of a single high-dose of oral vitamin D3 (stoss therapy) in children with inflammatory bowel disease (IBD) and hypovitaminosis D. Our secondary aim was to examine the safety of stoss therapy. Methods: We conducted a randomized, prospective study of 44 patients, ages 6 to 21 years, with IBD and 25-hydroxyvitamin D (25-OHD) concentrations <30 ng/mL. Patients were randomized to receive 50,000 IU of vitamin D3 once weekly for 6 weeks (standard of care, SOC group) or 300,000 IU once (stoss group). Serum 25-OHD levels were obtained at baseline, 4 and 12 weeks. Safety monitoring labs were performed at week 4. Results: Thirty-nine of 44 enrolled patients (19 stoss, 20 SOC) completed the study. Baseline vitamin D levels were not significantly different between the groups. Stoss therapy resulted in a substantial rise in 25-OHD levels at week 4, equivalent to the weekly regimen (53.6 +/- 17.3 vs 54.6 +/- 17.5 ng/mL). At week 12, serum 25-OHD levels decreased in both groups, significantly lower in the stoss group, but remained close to 30 ng/mL (29.8 +/- 7.1 vs 40.4 +/- 11.9 ng/mL,P = 0.04). A significant interaction with treatment group over time was observed (P = 0.0003). At the week-4 time point, all patients who received stoss therapy had normal serum calcium and PTH levels. Eighty percentage of patients preferred stoss therapy to the weekly regimen. Conclusions: Stoss therapy was safe and effective in raising 25-OHD in children with IBD commensurate to that of the weekly regimen.
Details
- Title: Subtitle
- Single High-dose Vitamin D3 Supplementation in Pediatric Patients With Inflammatory Bowel Disease and Hypovitaminosis D
- Creators
- Rose Lee - Nationwide Children's HospitalRoss M. Maltz - The Ohio State UniversityWallace Crandall - The Ohio State UniversitySteven W. Plogsted - Clinical Pharmacy-Nutritional Support Service.Ala K. Shaikhkhalil - The Ohio State UniversitySasigarn A. Bowden - The Ohio State UniversityEthan A. Mezoff - The Ohio State University
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.70(4), pp.E77-E80
- DOI
- 10.1097/MPG.0000000000002590
- PMID
- 31860537
- NLM abbreviation
- J Pediatr Gastroenterol Nutr
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 4
- Grant note
- 60129-0013-0001 / Nationwide Children's Hospital intramural grant
- Language
- English
- Date published
- 04/01/2020
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984353842002771
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