Single-subject oscillatory gamma responses in tinnitus

William Sedley; Sundeep Teki; Sukhbinder Kumar; Gareth Robert Barnes; Doris-Eva Bamiou; Timothy David Griffiths

doi:10.1093/brain/aws220

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Single-subject oscillatory gamma responses in tinnitus

Journal article

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Peer reviewed

Single-subject oscillatory gamma responses in tinnitus

William Sedley, Sundeep Teki, Sukhbinder Kumar, Gareth Robert Barnes, Doris-Eva Bamiou and Timothy David Griffiths

Brain (London, England : 1878), Vol.135(10), pp.3089-3100

09/13/2012

DOI: 10.1093/brain/aws220

PMCID: PMC3470708

PMID: 22975389

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https://doi.org/10.1093/brain/aws220View

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Abstract

This study used magnetoencephalography to record oscillatory activity in a group of 17 patients with chronic tinnitus. Two methods, residual inhibition and residual excitation, were used to bring about transient changes in spontaneous tinnitus intensity in order to measure dynamic tinnitus correlates in individual patients. In residual inhibition, a positive correlation was seen between tinnitus intensity and both delta/theta (6/14 patients) and gamma band (8/14 patients) oscillations in auditory cortex, suggesting an increased thalamocortical input and cortical gamma response, respectively, associated with higher tinnitus states. Conversely, 4/4 patients exhibiting residual excitation demonstrated an inverse correlation between perceived tinnitus intensity and auditory cortex gamma oscillations (with no delta/theta changes) that cannot be explained by existing models. Significant oscillatory power changes were also identified in a variety of cortical regions, most commonly midline lobar regions in the default mode network, cerebellum, insula and anterior temporal lobe. These were highly variable across patients in terms of areas and frequency bands involved, and in direction of power change. We suggest a model based on a local circuit function of cortical gamma-band oscillations as a process of mutual inhibition that might suppress abnormal cortical activity in tinnitus. The work implicates auditory cortex gamma-band oscillations as a fundamental intrinsic mechanism for attenuating phantom auditory perception.

Magnetoencephalography

auditory cortex

gamma oscillations

mutual inhibition

Original

tinnitus

Details

Title: Subtitle: Single-subject oscillatory gamma responses in tinnitus
Creators: William Sedley - Newcastle University
Sundeep Teki - Wellcome Centre for Human Neuroimaging
Sukhbinder Kumar - Wellcome Centre for Human Neuroimaging
Gareth Robert Barnes - Wellcome Centre for Human Neuroimaging
Doris-Eva Bamiou - UCL Institute of Neurology
Timothy David Griffiths - University College London
Resource Type: Journal article
Publication Details: Brain (London, England : 1878), Vol.135(10), pp.3089-3100
DOI: 10.1093/brain/aws220
PMID: 22975389
PMCID: PMC3470708
NLM abbreviation: Brain
ISSN: 0006-8950
eISSN: 1460-2156
Publisher: Oxford University Press
Language: English
Date published: 09/13/2012
Academic Unit: Psychological and Brain Sciences; Neurosurgery
Record Identifier: 9984303907902771

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