Singleton Deletions Throughout the Genome Increase Risk of Bipolar Disorder

Dandan Zhang; Lijun Cheng; Yudong Qian; Ney Alliey-Rodriguez; John R Kelsoe; Tiffany Greenwood; Caroline Nievergelt; Thomas B Barrett; Rebecca McKinney; Nicholas Schork; Erin N Smith; Cinnamon Bloss; John Nurnberger; Howard J Edenberg; Tatiana Foroud; William Sheftner; William B Lawson; Evaritus A Nwulia; Maria Hipolito; William Coryell; John Rice; William Byerley; Francis McMahon; Thomas G Schulze; Wade Berrettini; James B Potash; Pamela L Belmonte; Peter P Zandi; Melvin McInnis; Sebastian Zöllner; David Craig; Szabolics Szelinger; Daniel Koller; Susan L Christian; Chunyu Liu; Elliot S Gershon

doi:10.1038/mp.2008.144

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Singleton Deletions Throughout the Genome Increase Risk of Bipolar Disorder

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Singleton Deletions Throughout the Genome Increase Risk of Bipolar Disorder

Dandan Zhang, Lijun Cheng, Yudong Qian, Ney Alliey-Rodriguez, John R Kelsoe, Tiffany Greenwood, Caroline Nievergelt, Thomas B Barrett, Rebecca McKinney, Nicholas Schork, …

Molecular psychiatry, Vol.14(4), pp.376-380

04/2009

DOI: 10.1038/mp.2008.144

PMCID: PMC2735188

PMID: 19114987

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Abstract

An overall burden of rare structural genomic variants has not been reported in Bipolar Disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genome wide copy number variant (CNV) survey of 1001 cases and 1034 controls using the Affymetrix SNP 6.0 SNP and CNV platform. Singleton deletions (deletions that appear only once in the dataset) more than 100 kilobases in length are present in 16.2% of BD cases in contrast to 12.3% of controls (permutation p = 0.007). This effect was more pronounced for age at onset of mania ≤ 18 years old. Our results strongly suggest that BD can result from the effects of multiple rare structural variants.

Details

Title: Subtitle: Singleton Deletions Throughout the Genome Increase Risk of Bipolar Disorder
Creators: Dandan Zhang - Department of Human Genetics, The University of Chicago, Chicago, IL
Lijun Cheng - Department of Human Genetics, The University of Chicago, Chicago, IL
Yudong Qian - Department of Human Genetics, The University of Chicago, Chicago, IL
Ney Alliey-Rodriguez - Department of Human Genetics, The University of Chicago, Chicago, IL
John R Kelsoe - Department of Human Genetics, The University of Chicago, Chicago, IL
Tiffany Greenwood - Department of Human Genetics, The University of Chicago, Chicago, IL
Caroline Nievergelt - Department of Human Genetics, The University of Chicago, Chicago, IL
Thomas B Barrett - Department of Human Genetics, The University of Chicago, Chicago, IL
Rebecca McKinney - Department of Human Genetics, The University of Chicago, Chicago, IL
Nicholas Schork - Department of Human Genetics, The University of Chicago, Chicago, IL
Erin N Smith - Department of Human Genetics, The University of Chicago, Chicago, IL
Cinnamon Bloss - Department of Human Genetics, The University of Chicago, Chicago, IL
John Nurnberger - Department of Human Genetics, The University of Chicago, Chicago, IL
Howard J Edenberg - Department of Human Genetics, The University of Chicago, Chicago, IL
Tatiana Foroud - Department of Human Genetics, The University of Chicago, Chicago, IL
William Sheftner - Department of Human Genetics, The University of Chicago, Chicago, IL
William B Lawson - Department of Human Genetics, The University of Chicago, Chicago, IL
Evaritus A Nwulia - Department of Human Genetics, The University of Chicago, Chicago, IL
Maria Hipolito - Department of Human Genetics, The University of Chicago, Chicago, IL
William Coryell - Department of Human Genetics, The University of Chicago, Chicago, IL
John Rice - Department of Human Genetics, The University of Chicago, Chicago, IL
William Byerley - Department of Human Genetics, The University of Chicago, Chicago, IL
Francis McMahon - Department of Human Genetics, The University of Chicago, Chicago, IL
Thomas G Schulze - Department of Human Genetics, The University of Chicago, Chicago, IL
Wade Berrettini - Department of Human Genetics, The University of Chicago, Chicago, IL
James B Potash - Department of Human Genetics, The University of Chicago, Chicago, IL
Pamela L Belmonte - Department of Human Genetics, The University of Chicago, Chicago, IL
Peter P Zandi - Department of Human Genetics, The University of Chicago, Chicago, IL
Melvin McInnis - Department of Human Genetics, The University of Chicago, Chicago, IL
Sebastian Zöllner - Department of Human Genetics, The University of Chicago, Chicago, IL
David Craig - Department of Human Genetics, The University of Chicago, Chicago, IL
Szabolics Szelinger - Department of Human Genetics, The University of Chicago, Chicago, IL
Daniel Koller - Department of Human Genetics, The University of Chicago, Chicago, IL
Susan L Christian - Department of Human Genetics, The University of Chicago, Chicago, IL
Chunyu Liu - Department of Human Genetics, The University of Chicago, Chicago, IL
Elliot S Gershon - Department of Human Genetics, The University of Chicago, Chicago, IL
Resource Type: Journal article
Publication Details: Molecular psychiatry, Vol.14(4), pp.376-380
DOI: 10.1038/mp.2008.144
PMID: 19114987
PMCID: PMC2735188
NLM abbreviation: Mol Psychiatry
ISSN: 1359-4184
eISSN: 1476-5578
Language: English
Date published: 04/2009
Academic Unit: Psychiatry
Record Identifier: 9984003414102771

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