Sinonasal NUT-Midline Carcinoma – A Multimodality Approach to Diagnosis, Staging and Post-Surgical Restaging

Faiq Shaikh; Nitin Pagedar; Omer Awan; Parren McNeely

doi:10.7759/cureus.288

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Sinonasal NUT-Midline Carcinoma – A Multimodality Approach to Diagnosis, Staging and Post-Surgical Restaging

Journal article

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Sinonasal NUT-Midline Carcinoma – A Multimodality Approach to Diagnosis, Staging and Post-Surgical Restaging

Faiq Shaikh, Nitin Pagedar, Omer Awan and Parren McNeely

Curēus (Palo Alto, CA), Vol.7(7), p.e288

07/2015

DOI: 10.7759/cureus.288

PMCID: PMC4523209

PMID: 26244120

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https://doi.org/10.7759/cureus.288View

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Abstract

Nuclear protein testis (NUT) midline carcinoma is a rare malignancy involving predominantly the midline structures of the body. It is characterized by its genotypic feature of BRD4-NUT translocation, which is in contrast with other malignant processes that are usually categorized based on their histologic/phenotypic features. As these tumors may vary in their histologic presentation, they can be misdiagnosed as poorly differentiated carcinomas. Moreover, they are often very aggressive and associated with high mortality. Therefore, it is extremely important to diagnose them early using computed tomography (CT) and magnetic resonance imaging (MRI) and perform staging and restaging using 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT), in addition to accurately identifying them at a microscopic and molecular level. We report a unique case of a sinonasal NUT midline carcinoma that was diagnosed with CT, staged with PET/CT, and restaged using PET/CT and MRI.

mri

Radiology

midline carcinoma

sinonasal

Oncology

multimodality

nut

pet-ct

Details

Title: Subtitle: Sinonasal NUT-Midline Carcinoma – A Multimodality Approach to Diagnosis, Staging and Post-Surgical Restaging
Creators: Faiq Shaikh - Imaging Informatics, University of Pittsburgh Medical Center
Nitin Pagedar - Otolaryngology - Head and Neck Surgery, University of Iowa Hospitals & Clinics, Iowa City, IA
Omer Awan - Department of Radiology, Dartmouth Hitchcock Medical Center
Parren McNeely - Department of Radiology, University of Iowa Hospitals & Clinics, Iowa City, IA
Resource Type: Journal article
Publication Details: Curēus (Palo Alto, CA), Vol.7(7), p.e288
DOI: 10.7759/cureus.288
PMID: 26244120
PMCID: PMC4523209
NLM abbreviation: Cureus
ISSN: 2168-8184
eISSN: 2168-8184
Publisher: Cureus; Palo Alto (CA)
Language: English
Date published: 07/2015
Academic Unit: Radiology; Otolaryngology
Record Identifier: 9984051523602771

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