Journal article
Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI
Annals of the American Thoracic Society
08/10/2026
DOI: 10.1093/annalsats/aaoag235
PMID: 42576320
Abstract
Evaluate if early therapeutic initiation may begin ameliorating olfactory dysfunction in addition to chronic rhinosinusitis in young children with cystic fibrosis.
Participants ≤ 10 years were enrolled across six U.S. cystic fibrosis centers (May 2023-December 2024). Data were collected at baseline and one year following therapeutic initiation. Mixed-effects models were adjusted for age, sex, and nasal steroid use.
Sinus magnetic resonance imaging analysis included sinus volume, sinus opacification, olfactory bulb volume, olfactory cleft opacification, Lund-Mackay, and CRS-MRI scores. Psychophysical olfactory testing and quality of life assessments included the Pediatric Smell Wheel, Brief Questionnaire of Olfactory Disorders, EuroQol-5-Dimensions-Youth, and Sinonasal-5.Main Results: 31 participants (mean age 4.8 years) enrolled, 27 initiated treatment, and 26 completed follow-up (mean treatment duration 1.0 years). Following therapy, three olfactory measures improved: odor identification scores increased by 1.3 points (p = 0.03), olfactory bulb volume increased by 7.4mm3 (p = 0.02), and olfactory cleft opacification decreased by 14.4% (p = 0.004). Sinus opacification, Lund-Mackay, and CRS-MRI scores improved by 25.5% (p = 0.001), 5.0 points (p = 0.002) and 7.0 points (p = 0.005), respectively. Quality of life scores remained at near-normal levels.
Children receiving therapy demonstrated improvements in olfactory function, olfactory structure, and sinonasal opacification. Predominantly stable, near-normal quality of life metrics preliminarily suggest symptom-based instruments alone may be insufficient to identify sinonasal disease and treatment response at this age.
Details
- Title: Subtitle
- Sinusitis and Olfaction Improve in Young Children with Cystic Fibrosis Treated with ETI
- Creators
- Janice J Chung - University of California, Los AngelesEugene Oh - University of California, Los AngelesMichelle J Lee - University of California, Los AngelesJakob L Fischer - University of California, Los AngelesNina Wade - University of California, Los AngelesJason C Woods - Cincinnati Children's Hospital Medical CenterEdith T Zemanick - Children's Hospital ColoradoRhea Churi - University of California, Los AngelesRachael Buckingham - Seattle Children's Research InstituteSean B Fain - University of IowaDeborah Froh - University of VirginiaSonya L Heltshe - Seattle Children's HospitalLucas R Hoffman - University of WashingtonStephen M Humphries - University of California, Los AngelesChristine J Kim - University of California, Los AngelesElizabeth L Kramer - University of CincinnatiMichael Lewis - University of Kansas Medical CenterDouglas A Li - University of California, Los AngelesJaime Mata - University of VirginiaSarah S Milla - University of Colorado AnschutzPeter J Niedbalski - University of Kansas Medical CenterKatie L Ode - University of IowaBonnie Ramsey - Seattle Children's Research InstituteDaniella K Safatian - University of California, Los AngelesBenjamin D Sawatzky - University of VermontJillian S Sullivan - University of VermontAndrew T Trout - University of CincinnatiMyung Shin Sim - University of California, Los AngelesChristopher H Goss - University of WashingtonJennifer L Taylor-Cousar - National Jewish HealthDaniel M Beswick - University of California, Los Angeles
- Resource Type
- Journal article
- Publication Details
- Annals of the American Thoracic Society
- DOI
- 10.1093/annalsats/aaoag235
- PMID
- 42576320
- NLM abbreviation
- Ann Am Thorac Soc
- ISSN
- 2325-6621
- eISSN
- 2325-6621
- Publisher
- Oxford University Press
- Language
- English
- Electronic publication date
- 08/10/2026
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Endocrinology and Diabetes; Stead Family Department of Pediatrics
- Record Identifier
- 9985218634302771
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