Journal article
Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells
Environmental science. Nano, Vol.3(2), pp.365-374
04/01/2016
DOI: 10.1039/C5EN00271K
PMCID: PMC4917228
PMID: 27347420
Abstract
The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu 2+ and causing a differential impact on cytotoxicity.
Details
- Title: Subtitle
- Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells
- Creators
- Amaraporn Wongrakpanich - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United StatesImali A Mudunkotuwa - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United StatesSean M Geary - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United StatesAngie S Morris - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United StatesKranti A Mapuskar - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United StatesDouglas R Spitz - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United StatesVicki H Grassian - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United StatesAliasger K Salem - Departments of Chemistry and Biochemistry, Nanoengineering and the Scripps Institution of Oceanography, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States
- Resource Type
- Journal article
- Publication Details
- Environmental science. Nano, Vol.3(2), pp.365-374
- DOI
- 10.1039/C5EN00271K
- PMID
- 27347420
- PMCID
- PMC4917228
- NLM abbreviation
- Environ Sci Nano
- ISSN
- 2051-8153
- eISSN
- 2051-8161
- Publisher
- Royal Society of Chemistry (RSC)
- Language
- English
- Date published
- 04/01/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Occupational and Environmental Health; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Radiation Oncology; Craniofacial Anomalies Research Center; Chemistry; Dental Research; Chemical and Biochemical Engineering
- Record Identifier
- 9983985968602771
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